Safety of Health Workers During Hyperthermic Intraperitoneal Chemotherapy Procedure
Journal Title: Türk Kolon ve Rektum Hastalıkları Dergisi - Year 2017, Vol 27, Issue 4
Abstract
Peritoneal carcinomatosis (PC) is often considered an end-stage condition. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as the only potentially curative treatment for PC. This multimodal procedure involves aggressive multivisceral resections and peritonectomy aimed at achieving a complete cytoreduction, with no macroscopic residual tumor volume within the abdomen. After surgery, a heated chemotherapy perfusate is administered intraoperatively into the abdomen to cover all peritoneal surfaces. Thus, sufficient intraabdominal chemotherapeutic drug concentration can be achieved without systemic side effects. Hyperthermia enhances the effect of intraperitoneal chemotherapy by increasing peritoneal blood flow, by direct cytotoxic effect, and by altering the tumor microenvironment. During this procedure, the health worker is at risk of exposure to cytotoxic agents at various stages (such as through air contamination or direct contact during manipulation of perfusates or chemotherapy solutions and manipulation of objects/tissues exposed to chemotherapeutics). In addition, the use of high-voltage electrocautery during the removal of both peritoneal surfaces and tumor deposits during CRS exposes the health worker to large amounts of surgical smoke for extended periods of time. Inhalation of this smoke may pose a risk to the health-care worker. Guidelines for the safe implementation of CRS and HIPEC have not yet been established. This study summarizes the current evidence on security considerations of CRS and HIPEC management.
Authors and Affiliations
Koray Topgül, Zafer Malazgirt, Tayfun Bişgin
Keywords
Related Articles
- EP ID EP274112
- DOI 10.4274/tjcd.50251
- Views 137
- Downloads 0
Duration of the Sypmtoms Influence the Outcome after Botulinum Toxin Injection in Anal Fissure
Aim: To assess the effect of duration of the symptoms on outcome after botulinum toxin injection in anal fissure treatment. Method: Data of the patients who underwent botulinum toxin injection for chronic anal fissur wer...
Comparing Cosmetic Results of Purse-String Closure vs Conventional Linear Sutured Closure of the Stoma Wound Following Loop Ileostomy Reversal
Aim: Currently, conventional linear sutured closure of the skin following loop ileostomy reversal is widely used. Recently, The purse-string closure technique has been described as an approach associated with less wound...
Ischemic Colitis Mimicking Colorectal Carcinoma
.
Safety of Health Workers During Hyperthermic Intraperitoneal Chemotherapy Procedure
Peritoneal carcinomatosis (PC) is often considered an end-stage condition. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as the only potentially curative treatment for PC....
Decision Making in Surgical Oncology
As can be seen from ancient Egyptian writings, cancer has been a major health problem for at least 3.500 years. Significant progress has been achieved in the battle against cancer in conjunction with increased knowledge...