Safety of tolfenamic acid following repeated Intramuscular administration in wistar rats.
Journal Title: Pharma Science Monitor-An International Journal Pharmaceutical Sciences - Year 2011, Vol 2, Issue 2
Abstract
Tolfenamic acid (TA) is a non-steroidal anti-inflammatory agent of the fenamate sub-group. Safety of Tolfenamic acid (4 mg/kg) after daily intramuscular administration for 14 days was evaluated in wistar rats. Repeated administration of tolfenamic acid in wistar rats was found safe based on evaluation result of haematological and serum biochemical (Blood glucose, AST, ALT, ALP, total bilirubin, serum total protein, serum albumin, globulin, creatinine, urea and uric acid) parameters as well as Gross lesions and histopathology of liver, kidney, stomach, intestine, heart, spleen, joint cartilage and muscles of injection site. Significant changes in absolute and relative organ weights in tolfenamic acid treated rats have not been observed. Tolfenamic acid can be administered repeatedly by intramuscular injection without side effects.
Authors and Affiliations
S Patel, K Sadariya, A Gothi, Urvesh Patel, M Jain
Keywords
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Safety of tolfenamic acid following repeated Intramuscular administration in wistar rats.
Tolfenamic acid (TA) is a non-steroidal anti-inflammatory agent of the fenamate sub-group. Safety of Tolfenamic acid (4 mg/kg) after daily intramuscular administration for 14 days was evaluated in wistar rats. Repeated...