Saliva as a biomarker of heat shock protein 70 in poor oral health
Journal Title: International Journal of Applied Dental Sciences - Year 2016, Vol 2, Issue 4
Abstract
Background: The Heat shock proteins are stress induced and there is increased evidence of presence of these chaperons extracellular which is considered to be intracellular. Their present cytokine like effect and help in immune recognition, thus indicate strong extracellular action of heat shock protein 70 in maintaining integrity of oral cavity. Hypothesis: The aim of this study was to evaluate the Circulatory and salivary heat shock protein level 70 in healthy individuals and individuals with poor oral health. Evaluation: Settings and Design: 80 patients attending to the outpatient department of A.B. Shetty memorial institute of dental sciences, Mangalore during the period of October 2015 to November 2015 were included in the study. Control group (N=40) includes healthy individuals with good oral hygiene (OHIS SCORE > 3) and Experimental group (N=40) includes individuals with poor oral hygiene (OHIS< 3). Methods and Material: Saliva and serum samples were evaluated for Heat shock protein 70 levels in test and control group by ELISA kit method. Statistical analysis used: Student’s t test was used for statistical analysis, which was expressed in terms of mean and standard deviation. P<0.05 was considered to be statistically significant. Results: There was a significant increase in Serum Heat shock protein 70 levels in Experimental group (5.87 ng/ml) in comparison with the control group (3.170ng/ml). Salivary Heat shock protein 70 shock showed significant levels in experimental levels (4.21 ng/dl) compared to control group (2.641ng/dl) Conclusions: Heat shock proteins 70 are efficient cell stress marker in poor oral health condition
Authors and Affiliations
Dr. Mithra N Hedge, Nireeksha . , Dr. Suchetha Shetty
Innovation in regeneration – Concentrated growth factor
Regenerative medicine is one of the most dominant objectives of today’s rehabilitation therapies. In dentistry, many researches of growth factors applicable to bone regeneration techniques recognised that the best tissue...
Anatomical miscellany in molars: Their endodontic management
Root canal anatomy is highly complex and unpredictable. Success of endodontic treatment depends on proper identification of all the canals, thorough chemo-mechanical preparation followed by three dimensional obturation w...
An unusual presentation of Facial paralysis: A case report
Facial paralysis is a neuropathy of the peripheral seventh cranial nerve, usually resulting from traumatic, compressive, infective, inflammatory or metabolic abnormalities. However, in many cases no etiology is identifie...
Hybrid Richmond crown - A novel technique for reattachment of complicated fractured crown segment: A case report
Background: Maxillary central incisor is most commonly affected tooth during trauma followed by maxillary lateral incisor and mandibular incisors. Trauma to the anterior tooth requires urgent care because of essentiality...
Smart seal: Unique obturation system in dentistryq
Newly introduced root canal obturating system “SmartSeal” is established on the polymeric technology. The hydrophilic nature of the obturating points can absorb surrounding moisture and expand, resulting in filling of vo...