Salivary Alkaline Phosphatase- A Risk Indicator in Hemodialysis Patients with Chronic Periodontitis
Journal Title: Journal of Contemporary Medicine and Dentistry - Year 2018, Vol 6, Issue 3
Abstract
bone destruction and ultimately tooth loss. Alkaline phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules and is a marker of bone metabolism. Elevated total serum alkaline phosphatase (ALP) values have been associated with increased mortality in the hemodialysis patients and also in the general population. Methods: The study included 20 subjects, 10 in each group in the age group of 30-50 years. Group A comprised of 10 systemically healthy individuals with chronic periodontitis. Group B comprised of 10 hemodialysis dependent Chronic kidney disorders (CKD) patients with chronic periodontitis. Results: The present study showed a significant increase in Alkaline Phosphatase value in hemodialysis-dependent CKD patients with chronic periodontitis (Group B) compared to systemically healthy subjects with chronic periodontitis (p value<0.005). Conclusion: Alkaline phosphatase could be used as a diagnostic marker of periodontitis in hemodialysis-dependent CKD patients. However, ALP cannot be solely responsible for periodontitis in hemodialysis dependent CKD patients but it can be used as an additional aid in diagnosing periodontitis.
Authors and Affiliations
Sajna H. R. , Amitha Ramesh, Biju Thomas, Santhosh Shenoy
Keywords
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