Salivary Amylase as a Biomarker in Health and Periodontal Diseases
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction: Amylase is a key protein secreted in the saliva as a part of oral host immune response in periodontal disease. To detect its level according to the severity of periodontal disease, the present study was conducted to evaluate and compare salivary amylase level in healthy, gingivitis and chronic periodontitis subjects. Material and Methods: In this case-control, cross sectional study, a total of 45 subjects (15 healthy, 15 gingivitis, 15 chronic periodontitis) were divided into groups A, B and C respectively. All groups were evaluated for salivary amylase and other clinical parameters at baseline and 6 weeks after scaling. Whole saliva samples were collected and amylase evaluation was carried out by kinetic assay method. The results were analyzed by ANOVA and paired âtâ test. Results: The results of this study showed that the level of amylase in subjects with gingivitis and chronic periodontitis was significantly higher than healthy controls (P < 0.001). After periodontal treatment, an amylase level decreased in gingivitis and chronic periodontitis subjects. Conclusion: The results showed that there is a significant relationship between the level of salivary amylase and periodontal disease. Its level changes as per the inflammation of periodontal disease. An amylase may be considered as an inflammatory biomarker in periodontal disease.
Authors and Affiliations
Thakur Neha P, Mhaske Maya, Rakhewar Purushottam S
Keywords
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