Salivary Biomarkers to Monitor Osteopenia and Stress Levels in Breast Cancer Survivors
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 19, Issue 5
Abstract
Aims: The aim of this study is to assess salivary biomarkers, i.e. cortisol, calcium, phosphate, osteocalcin, vitamin D and estradiol levels, to monitor osteopenia and stress levels in post-treatment breast cancer patients. Methods: The salivary biomarkers of forty-five female breast cancer survivors aged between 30 to 48 years were compared against twenty-eight disease-free, healthy female subjects, which act as the reference values in our study. Saliva collection was done by resting/drooling collection method (minimal oral movements). The independent unpaired t-test was used to compare the differences between the parameters of control group and patient group. Results: The salivary flow rate and the amount of saliva were not significantly different between both groups. The concentration of salivary cortisol in breast cancer survivors was significantly higher compared to healthy controls (P<0.01). The mean concentrations of salivary calcium (P<0.01), phosphate (P<0.05), osteocalcin (P<0.001), vitamin D (P<0.001) and estradiol (P<0.05) in the breast cancer survivor group were significantly lower than those in the control group. Conclusion: Our findings suggest that the measurement of salivary biomarkers can be considered as a useful method to monitor osteopenia and stress levels in breast cancer survivors.
Authors and Affiliations
Xun Xiao, Michael C. W. Yip, Wings T. Y. Loo, Liang Hao, Louis W. C. Chow, Erich F. Lie, Christopher Y. C. Chow, Min Wang
Keywords
Related Articles
- EP ID EP310993
- DOI 10.9734/BJMMR/2017/30663
- Views 78
- Downloads 0
Hysteroscopic Embryo Transfer or Implantation- Experience of a Decade: An Alternative Objective and Reliable Method for Embryo Transfer (HEED) and Implantation (SEED)
Aims: Here we present early experience using HEED and SEED along with a description of these procedures in more detail. There is also a new look at the endometrial cavity and the placement of embryo transfer or implantat...
Ascitic Fluid Fibronectin: A Marker to Differentiate Between Malignant and Non-malignant Ascites
Background and Aims: So far, the differentiation between malignant and non-malignant ascites by laboratory parameters has not been fully achieved yet. Fibronectin is a glycoprotein which plays an important role in cell a...
An Unexpected Increase in Adult Appendicitis in England (2000/01 to 2012/13): Could Cytomegalovirus (CMV) be A Risk Factor?
Aims: To study the trends in admission for diseases of the appendix and to attempt to present a potential basis for the observed (complex) age-dependent trends and etiologies. Study Design: Longitudinal study of admissio...
The Prevalence and the Predictors of Complementary and Alternative Medicine among Children on Highly Active Antiretroviral Therapy in Makurdi, Nigeria
Aims: To determine the prevalence, the pattern of usage and the predictors of complementary and alternative medicine (CAM) among children on highly active antiretroviral therapy (HAART). Study Design: Prospective, Cross...
Cytology Services Utilisation Pattern in North-Central Nigeria
Context: Cytology is a simple, fast, low cost, minimally invasive and sensitive technique for evaluating cells sampled from lesions in the body. It is an aspect of pathology service at its fledgling stage in most institu...