Salivary CYFRA 21-1 in patients of oral squamous cell carcinoma and premalignant lesions
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 4
Abstract
Introduction: Oral squamous cell carcinoma (OSCC) accounts for about 90% of malignant oral lesions, and is widely recognized as the most frequently occurring malignant tumour of oral cavity with an incidence rate of 14.9-25.6 per 100,000. However in India and other Asian countries, there is a particularly high prevalence even amongst younger people which is being attributed to the influence of region specific epidemiological factors, especially heavy use of tobacco and betel quid chewing. In spite of diagnostic and therapeutic advances over the decades, OSCC still remains a challenge for medical professionals with the five year survival rate being 30%-50%. Aims and Objective: Human saliva is an attractive diagnostic fluid because saliva collection is noninvasive as compared to the collection of blood for serum/ plasma analyses. Our aim was to estimate the levels of salivary CYFRA 21-1(Human Cytokeratin fragment antigen 21-1) in oral premalignant lesion patients as a biomarker for early detection of OSCC. Materials and Method: Saliva was collected from a total of 62 patients of both OSCC and premalignant oral lesions along with their respective biopsies. Salivary levels of CYFRA 21-1 was estimated by Enzyme Linked Immunosorbent Assay (ELISA) and their readings were correlated with the histological diagnoses of their respective biopsies and comparison was done with the salivary CYFRA 21-1 levels of healthy controls. Result: CYFRA 21-1 can be a novel biomarker for oral squamous cell carcinoma. Histologically and clinically results were found to be correlated. Comparison of salivary CYFRA 21-1 among the groups showed an increasing trend ranging from lowest value in the control group to higher in the premalignant group and the highest value in OSCC patients, the difference was significant amongst all three groups. ROC (Receiver Operating Characteristic) curve analysis of CYFRA 21-1 levels in all three groups showed a highly sensitive test with good test results.
Authors and Affiliations
Pretty Singh, Riddhi Jaiswal, S M Natu, M M Goel, Wahid Ali, Veerendra Verma
Keywords
Related Articles
- EP ID EP191908
- DOI -
- Views 106
- Downloads 0
Bonemarrow fibrosis condition with various underlying disorders
Introduction: Bone marrow fibrosis is a common morphological finding in trephine biopsies. It can be of various grades and severity in various lesions. The reticulin and collagen fibers are identified by using reticulin...
The incidence of heart failure in diabetics with stable coronary artery disease
Background and Objectives: Human brucellosis is an important but neglected disease in India. It is traditionally described as a disease of protean manifestations. The aim of this study was to access the epidemiological,...
A rare case of a swollen knee due to single large synovial chondroma
Introduction: A synovial chondromatosis is a rare benign neoplasm on the synovium. Although described as a benign disease, it can be very destructive and can cause severe osteoarthritis and pain. Case presentation: A 58-...
Seasonality of malaria in and around Aurangabad district, Marathwada region of Maharashtra, India
Background: Malaria is a serious public health issue in developing countries. The present study was aimed to observe seasonal variation of malaria in our region. Methods: A retrospective record base study was carried out...
Efficacy of serum ascites albumin gradient and ascitic fluid protein in determining ascites etiology
Introduction: The pathologic accumulation of fluid in the peritoneal cavity denotes the term ‘ascites’. The various causes of ascites may be classified into two broad patho-physiologic categories, first one is associated...