Salivary Total Antioxidant Activity as a Non Invasive Biomarker for Oxidative Stress In Asthmatic Patients
Journal Title: National Journal of Integrated Research in Medicine - Year 2012, Vol 3, Issue 1
Abstract
Background: Bronchial Asthma is a chronic inflammatory disease along with hyperresponsiveness of bronchi. The present study was designed to assess the redox status of patients suffering from bronchial asthma and to compare it with that of normal healthy controls, by determining the total antioxidant activity (AOA) of the serum and saliva and correlating it with the disease status. Method: Total AOA was assayed spectrophotometrically in saliva and serum of two groups; asthmatic patients attending OPD of pulmonary Medicine and healthy controls. The patients were followed for a period of three months after start of therapy and total AOA was measured post therapy. Results: Asthmatic patients exhibited significantly(p<0.05) decreased serum and salivary total AOA as compared to healthy controls. Decreased contents of total AOA in serum and saliva was positively correlated with the severity of disease process. Total AOA in serum was significantly (p<0.0001) higher than salivary AOA in all the categories of asthmatic patients. Total AOA in serum was significantly (p<0.0001) higher than that in saliva of the control subjects. The depressed total AOA returned to near normal values post treatment. In Conclusion: Total AOA in serum and saliva is a good indicator for assessing the severity and progress of bronchial asthma. Salivary total AOA can be taken as a potential biomarker for oxidative stress in asthmatic patients
Authors and Affiliations
K Sayedda, Q S Ahmed
Keywords
Related Articles
- EP ID EP140289
- DOI -
- Views 100
- Downloads 0
A Study to Correlate Cephalic Index Of Various Caste/Races Of Gujarat State
The study was carried out in various communities of Gujarat state which are still occupying particular locations of various districts in different regions. Total six communities were selected randomly. These wer...
Velamentous insertion of umbilical cord in twin pregnancy
Lifeline of the fetus in the womb is umbilical cord and is not spared in having anatomical and functional variance. Velamentous insertion of umbilical cord is more common in twins (incidence 8.7%). Increased risk for int...
Application Based Learning Through Hospital Projects For Teaching Microbiology To Medical Students
Microbiology in-spite of being a crucial subject for understanding the basic principles with their application in infectious disease fails to impress the undergraduate medical students probably because they are taught...
Histiocytic Necrotising Lymphadenitis (Kikuchi's Disease) [A 5 Year Histomorphological Study]
Background: Kikuchi’s disease is a rare, benign, self-limiting disease, mainly involving the lymph nodes of young people. The disease has unknown etiology. Clinical symptoms and basic investigations in a patient often...
Diaphysial Nutrient Foramina In Long Bones And Miniature Long Bones
Background: Nutient foramen is an opening into the bone shaft which gives passage to the blood vessels of the medullary cavity of a bone. The knowledge of nutrient foramen is important in surgical procedures l...