SCREENING AND DIAGNOSTIC CRITERIA FOR GESTATIONAL DIABETES MELLITUS – CHANGES WORLDWIDE OVER TIME
Journal Title: Romanian Journal of Diabetes Nutrition and Metabolic Diseases - Year 2011, Vol 18, Issue 2
Abstract
Gestational diabetes mellitus (GDM) is defined as a glucose intolerance with first onset or first recognition during pregnancy. GDM is associated with higher incidence of maternal and fetal complications. Screening for GDM is recommended in most pregnant women. Assessment of risk for GDM should be performed at first prenatal visit and women at very high risk should be screened immediately using a random, fasting or post-glucose load glucose level. Most women not found to have GDM should undergo further screening at 24-28 weeks of gestation. Despite four international conferences aimed at developing a consensus definition and diagnostic criteria for GDM worldwide, the definition, screening and diagnostic criteria vary over the time making difficult to compare prevalence between countries. Most centers in Europe use World Health Organisation (WHO) diagnostic criteria which are the same as in the general population and use a 75g oral glucose tolerance test (OGTT). Current criteria used in US are based on two different protocols using one or two step-approach, 75g or 100g OGTT. Results of Hyperglycemia and Adverse Pregnancy Outcome released in 2008 have indicated a strong, continuous association between blood glucose levels below those currently used for diagnostic of diabetes and undesirable perinatal outcomes. Since the HAPO study, new, lower thresholds were proposed for the diagnostic of GDM. Implementation of these thresholds will almost double the proportion of women diagnosed with GDM.
Authors and Affiliations
Luiza Radu, Gabriela Negrisanu, Ioan Romosan
Keywords
Related Articles
- EP ID EP113620
- DOI -
- Views 97
- Downloads 0
HYPOGONADISM IN METABOLIC SYNDROME PATIENTS
Introduction. Previous studies have shown a high prevalence of low levels of the endogenous sexual hormones in patients with metabolic syndrome (MetS). The aim of this study was to analyze the prevalence of hypogonadism...
RESISTIN AND HIGH GLUCOSE CONCENTRATIONS-ACTIVATION OF HUMAN SMOOTH MUSCLE CELLS INDUCES ENHANCED MONOCYTE CHEMOTAXIS
Objectives. Recent data indicate that upon activation by resistin and high glucose concentrations (HG) vascular smooth muscle cells (SMC) acquire pro-inflammatory properties. We questioned whether resistin and HG-a...
EFFECT OF HLA-DR GENOTYPES ON THE CLINICAL MANIFESTATIONS AT THE ONSET OF TYPE 1 DIABETES IN A GROUP OF PATIENTS FROM CONSTANTA COUNTY
Type 1 diabetes mellitus (T1DM) is a metabolic disease with multifactorial etiology characterized by β-cell autoimmune processes. The strongest genetic determinants were proved to be class II genes of the major histocomp...
DIABETES MELLITUS EPIDEMIOLOGY
The worldwide diabetes epidemics is evolving proportionally with the overweight/obesity epidemics. 246 million people with diabetes (type 2 diabetes constituting about 90%) were registered worldwide in 2007. It was estim...
Glucose Variability In Persons With Diabetes Evaluated By Continuous Glucose Monitoring
Blood glucose level is the main indicator of diabetes control. It is related to diabetes evolution and appearance of chronic complications. Daily and/or postprandial glucose fluctuations induce oxidative stress and endot...