Abstract

Background: The Familial hypercholesterolemia (FH), is defined by LDL-c since 150 mg/ml (4.0 mmol/L) or more and Total Cholesterol 300 mg/ml or more, it is an inherited disease of two types, estimated frequency 1:400, for heterozygotes (He) and 1:1,000,000 homozygotes (Ho) we did the detection in general population, using the Dutch Lipid Register Network. Methods: In the city Manaus, Amazonas, with the Dutch Lipid Register Network. Were analyzed 1294 lipid profiles, of the North and West zone of city, neither with DMII, between June 2014 and March 2015, from people aged range 18 to 77 years old. Whose clinical history of familial cardiovascular disease (CVD) was wondered. Outcomes: Incidence of 1:45, without genetics study just applying the Dutch, Lipid Register Network, average Cholesterol total 297 mg/ml, (7.78 mmO/L), LDL-C.199 mg/ml (5.13 mmO/L), HDLc.58 mg/ml and Positive Familial History for CVD. Conclusions: FH is important to improve the efforts in medical staff and prevent disease of heart attack in the stage early. Without cost just reviewed, laboratory studies of routine considered, of course, those results aren´t definitive or conclusive, later the genetic test can be done to confirm the FH.

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