Screening of analgesic activity of Phoenix sylvestris leaves in rodents
Journal Title: Journal of Ayurvedic and Herbal Medicine - Year 2018, Vol 4, Issue 1
Abstract
Aim: The present study evaluated the central and peripheral analgesic activity of methanolic leaf extract of Phoenix sylvestris (PSLME) in swiss albino mice. Method: Peripheral and central analgesic activity was evaluated by tail immersion and acetic acid writhing in swiss albino mice. Dextropropoxyphene was used as a standard drug in the dose of 65mg/kg body weight in both models. PSLME was tested at 100 and 500mg/kg dose level. Results: The result revealed that methanolic extract exhibit 48% and 40.5% writhing inhibition at 500 and 100 mg/kg doses whereas ~30% tail withdrawal reflexes inhibition at 500mg/kg which was analogous to the standard drug dextropropoxyphene. Conclusion: Methanolic extract of leaves of P. sylvestris possesses both peripheral and central analgesic activity in experimental animal.
Authors and Affiliations
Pankaj Jain, Sonika Jain, Surendra Kumar Swarnkar, Swapnil Sharma, Sarvesh Paliwal
Keywords
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