Screening of Anti-Diabetic Potential Of Hydro-Alcoholic Seeds Extract of Nigella Sativa in Streptozotocininduced Diabetic Rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Herbal drugs obtained from huge number of plants/herbs were extensively utilized in the prevention, diagnosis or treatment of various human diseases since ancient era. Recently, a research suggested that Nigella sativa exhibits an anti-diabetic effect by showing marked histopathological changes in kidney and pancreas of rats. So the present was designed to evaluate the anti-diabetic potential of hydro-alcoholic seeds extract of Nigella sativa in rat model.The fresh seeds of Nigella sativa were collected from the local market and identified & authenticated by botanist at National Botanical Research Institute (CSIR), RanaPratapMarg, Lucknow with the voucher specimen no. (NBRI-SOP-202), Reference no. (NBRI/CIF/296/2012).N. sativa seeds (black seeds) were fully shade dried and extracted using hydro-alcoholic solution (1:1). Animals were procured from the animal housing facility of SPS, IFTM University Moradabad (Reg. no. 837/ac/04/CPCSEA).Adult albino rats (200-250g) of either sex were used for the screening of the effect. The Body weight determination, Oral Glucose Tolerance Test (OGTT), Blood Glucose and SGOT and SGPT levelswere evaluated for its antidiabetic potential. In results, it significantly demonstrated the positive anti-diabetic in dose dependent manner. It clarifies its potent efficacy and safety concerns. In conclusion, it suggests identification and isolation of specific constituents being responsible for its noble pharmacological potential.
Authors and Affiliations
Mohdruman Khan, Dr. Vikassaxena .
Keywords
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