Screening of anti-hepatic steatosis action of Syzygium cumini on streptozotocin induced hepatic steatosis in diabetic rats
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 9, Issue 1
Abstract
Background: Hepatic steatosis is one of the important liver disease worldwide. The present study aimed to evaluate the anti-hepatic steatosis effect of Syzygium cumini in STZ induced hepatic steatosis in Wistar Albino rats. Materials and Methods: Wister Albino rats weighing 230-250gm were divided in to 5 groups. Diabetes induced in four groups by administration of streptozotocin (45mg/kg/i.p). Group-I serves as control and normal saline was administered. Group-II diabetic control, Group-III Diabetic control (Streptozotocin 45mg/kg/i.p/0day)+Glibenclamide (5mg/kg/orally/120 days), Group-IV: Diabetic control (Streptozotocin 45mg/kg/i.p/0day)+Aqueous extract of Syzygium cumini seeds (250mg/kg/orally/120 days) and Group-V: Diabetic control (Streptozotocin 45mg/kg/i.p/0day) + Aqueous extract of Syzygium cumini seeds (500mg/kg/orally/120 days). All the drugs were respective groups for 120 days. On 120th day rats were sacrificed and liver was isolated. Liver weight was measured. Liver specimens were stored in 10% formalin and used for histopathological study. ANOVA (post hoc) followed by Dunnet t teat applied to find the significant difference between the groups. Results: Group-II showed significant increase in liver weight, volume and fatty changes compared to Group-I. Group-III, IV and V significantly reversed the STZ induced changes in liver. Conclusion: Syzygium cumini extract showed decreased fatty changes in this study. It can be used in the treatment of non alcoholic fatty liver disease. More studies required to evaluate the mechanism how it produce the liver protective effect.
Authors and Affiliations
Swadhin Ranjan Behera
Keywords
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- EP ID EP471387
- DOI 10.26611/1010912
- Views 84
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