SCREENING OF ANTIOXIDANT ACTIVITIES AND THEIR BIOAVAILABILITY OF TROPICAL FRUIT BYPRODUCTS FROM INDONESIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 6
Abstract
Objective: The objectives of this study were to investigate the antioxidant activities in peel and seed of six tropical fruits from Indonesia and to evaluate their bioavailability by in vitro digestion model.Methods: Six tropical fruits namely kapundung, matoa, papaya, rambai salak and soursop were used. The study measured antioxidant activities through 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, thiobarbituric acid reactive substances (TBARS) assay, total phenolic and total flavonol content of the samples. Further, the bioavailability of the antioxidant was determined by in vitro gastrointestinal digestionResults: Matoa peel and salak peel exhibited high DPPH radical scavenging activity with a SC50values of 6.6 and 6.4 µg/ml, respectively. Soursop peel had the highest for inhibiting lipid peroxidation followed by matoa peel and salak peel. The highest value for total phenolic content had in salak peel (317.0 mg gallic acid equivalent (GAE)/g dry basis). Then, total flavonol content values in salak seed (96.7 mg quercetin equivalent (QE)/g dry basis) was the highest in this study. The antioxidant activity of matoa peel and soursop peel increased after being digested.Conclusion: The results obtained in the present study indicate that peels from matoa (Pometia pinnata) and soursop (Annona muricata L) could serve as potential sources of antioxidant for use in food or feed supplement, and pharmaceutical industries.Keywords: Antioxidant, Lipid peroxidation, Phenolic compounds, Fruit peel, Fruit seed, Tropical fruit
Authors and Affiliations
Ainissya Fitri, Mira Andriani, Asep Sudarman, Toto Toharmat, Lina Yonekura, Hirotoshi Tamura, Nahrowi Ramli
Keywords
Related Articles
- EP ID EP576316
- DOI -
- Views 42
- Downloads 0
THE THERAPEUTIC AND NEUROPROTECTIVE EFFECTS OF GREEN TEA IN A RAT MODEL OF TERLIPRESSIN-INDUCED CHRONIC HYPONATREMIA
Objective: Hyponatremia (HN) is associated with mortality and morbidity risks due to the development of hyponatremic encephalopathy. Its rapid correction also carries a high risk of development of the serious cerebral di...
SENNA PLANT INDUCES DISRUPTION ON THE MITOCHONDRIA OF HYMENOLEPIS DIMINUTA
Objective: The present study aims at observing the effects of three species of Senna plants, viz. Senna alata, S. alexandrina and S. occidentalis on the ultrastructure of the mitochondria of the tapeworm, Hymenolepis dim...
FORMULATION AND OPTIMIZATION OF SOLID SELF-NANOEMULSIFYING SYSTEM USING POROUS CARRIERS FOR ORAL DELIVERY OF CINNARIZINE
Objective: The present study aims to utilize the nanotechnology technique to formulate the Cinnarizine (CNZ) in the form of solid self-nano emulsifying system to enhance the dissolution and hence the bioavailability.Meth...
PHYSICAL MUTAGENESIS BASED STRAIN IMPROVEMENT OF ASPERGILLUS SP. FOR ENHANCED PRODUCTION OF LOVASTATIN
Objective: The present investigation aimed towards the strain improvement of lovastatin maximum yielding wild-type fungal strains (Aspergillus terreus-MTCC 11045, Aspergillus terreus-MTCC 11395 and Aspergillus flavus-MTC...
DESIGN, SYNTHESIS AND ANTIEPILEPTIC EVALUATION OF 5-(ARYL)-N-PHENYL-1,3,4-THIADIAZOL-2-AMINE
Epilepsy is one of the leading neurological disorders, which is a major threat to public health. Though, several new antiepileptic drugs are developed, the treatment of epilepsy remains still inadequate, and the patient...