SCREENING OF Cassia sieberiana (FABACEAE) LEAF EXTRACT FOR IN-VITRO ANTI MICROBIAL AND ANTI-ULCER ACTIVITIES
Journal Title: Progress in Chemical and Biochemical Research - Year 2019, Vol 2, Issue 3
Abstract
Study evaluates the in-vitro anti-microbial and anti-ulcer activity of Cassia sieberiana leaf extracts on Helicobacter pylori the major etiological agent of chronic active gastritis and peptic ulcer disease also called gastric carcinoma. Crude extracts of cassia sieberiana were screened for their antimicrobial and antiulcer activities. Antimicrobial assay and in-vitro anti-ulcer (H. pylori) was performed using Agar Diffusion Method and Broth Dilution Method. Ethyl acetate extract had the highest diameter of zones of inhibition (30 mm). Ethyl acetate and methanol extracts had the same Minimum inhibitory concentrations of 10 mg/mL against Streptococus feacalis, Escherichia coli, Helicobacter pylori, shigella dysenteriae and Candida stellafoidea but for Campylobacter jejuni which had a minimum inhibitory concentration at 20 mg/mL for methanol extract. Methanol extract had the best minimum bactericidal/fungicidal concentration (40 mg/mL) on the pathogens. The results showed that Cassia sieberiana exhibited strong antimicrobial activity against H. pylori at two different concentrations of 20, 40mg/mL.
Authors and Affiliations
Emmanuel Khan Muluh, Agustine Odokpe Ugbede, Terumon Amon Tor-Anyin
Keywords
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- EP ID EP634778
- DOI 10.33945/SAMI/PCBR.2019.2.7
- Views 54
- Downloads 0
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Study evaluates the in-vitro anti-microbial and anti-ulcer activity of Cassia sieberiana leaf extracts on Helicobacter pylori the major etiological agent of chronic active gastritis and peptic ulcer disease also called g...
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