Screening of Euphorbia hirta Leaves for Antipsoriatic Activity in Mice
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 1
Abstract
Abstract: Psoriasis is a skin disease that causes scaling and inflammation where the skin cells grow deep in the skin and slowly rise to the surface. Worldwide nearly 1 to 3% total population affected with psoriasis. This inflammatory disease is usually involves extensor surfaces and scalp and is now recognized to be mediated in part by immune alterations. Herbal remedies have been used effectively in skin disorders for thousands of years worldwide. Euphorbia hirta belongs to the plant family Euphorbiaceae and genus Euphorbia, widely used in various skin disorders. In order to validate its traditional claim, an attempt was made to evaluate the anti-psoriatic activity of 250 mg/kg ethanolic leaf extract of Euphorbia hirta in mouse tail test method. Isoretinoic acid was used as reference drug. Anti-psoriatic activity was assessed by measuring the Degree of Orthokeratosis and Relative Epidermal Thickness. Result shows that, Euphorbia hirta produced significant increase in Orthokeratosis and the Relative epidermal thickness compared to control. Present study concludes that, Euphorbia hirta exhibited anti-psoriatic activity and it may be considered for psoriasis and other skin disorders. Keywords: Psoriasis, Euphorbia hirta, Orthokeratosis and Isoretinoic acid
Authors and Affiliations
Harsha Vardhan K, Jaikumar S, Premlal KR
Keywords
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