SCREENING OF HERBAL LEAVES EXTRACT OF BOUGAINVILLEA GLABRA FOR DIABETIC NEPHROPATHY IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 6
Abstract
The main objective of this study was to investigate hypoglycemic effects of Bougainvillea glabra Leaves extract in Streptozotocin (STZ) induced hyperglycemic rats. The secondary objective of the study was to study effect of extract on biochemical parameters. Extract was prepared from leaves of Bougainvillea glabra by Soxhlet extraction method. Diabetes was induced in rats by using Streptozotocin and rats were divided into 6 groups namely control, Diabetic, treated groups at doses of 250 mg/kg, 500 mg/kg, 1000 mg/kg and Lisinopril treated group. Blood and Urine samples were collected for the estimation of Total Glycerides (TG), Serum Cholesterol, Total protein, Blood Urea Nitrogen (BUN), Serum Creatinine, Thiobarbituric acid reactive substance (TBARS) and Glutathione levels (GSH). The result showed positive effect of leaves extract to reduce hyperglycemia in treated group as compared to control group. Bougainvillea glabra extract at 1000 mg/kg dose showed efficient results.
Authors and Affiliations
Pankaj Verma , Shweta Sehrawat, Hema Chaudhary, Vikash Kumar
Keywords
Related Articles
- EP ID EP118137
- DOI 10.7897/2230-8407.07664
- Views 93
- Downloads 0
MICROWAVE ASSISTED SYNTHESIS AND EVALUATION OF FLUORO, CHLORO, 2-(α- SUBSTITUTED ARYL AMINO ACETAMIDO) BENZOTHIAZOLES DERIVATIVES FOR ANTIMICROBIAL ACTIVITY
A series of various substituted benzothiazole derivatives containing 7- chloro-6-fluoro-2-chloroacetamidobenzothiazole derivatives were synthesized and their structures were established by means of spectroscopic techniqu...
A REVIEW ON MASS SPECTROMETRY DETECTORS
Mass spectrometry is an analytical technique for "weighing" molecules. Obviously, this is not done with a conventional scale or balance. Instead, mass spectrometry is based upon the principle of the motion of a charged p...
HEPATOPROTECTIVE EFFECT OF AQUEOUS AND N-HEXANE EXTRACT OF NIGELLA SATIVA IN PARACETAMOL (ACETAMINOPHEN) INDUCED LIVER DISEASES OF RATS: A HISTOPATHOLOGICAL EVALUATION
Acute over dose of paracetamol (acetaminophen) causes serious hepatic necrosis. So, this study was conducted to observe the hepatoprotective activity of aqueous and n-hexane extract of Nigella sativa in paracetamol induc...
HOW TO LIVE WITH RHEUMATOID ARTHRITIS???
Rheumatoid Arthritis (RA) is a chronic auto-immune disease characterized by painful inflammation of the joints and surrounding tissues, leading to long term disability. Rheumatoid arthritis can begin at any age but has i...
EVALUATION OF ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF SEEDS OF PHYLA NODIFLORA LINN.
‘Jalapippali’ described in classical texts of Ayurveda is botanically identified as Phyla nodiflora Linn. (Syn. Lippia nodiflora Rich). In present study methanolic extract of seeds of Phyla nodiflora Linn. was screened...