SCREENING OF SELECTED BIOLOGICAL ACTIVITIES OF ARTOCARPUS LAKOOCHA ROXB (MORACEAE) FRUIT PERICARP
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 4
Abstract
Artocarpus lakoocha Roxb (Moraceae) is cultivated in Uttar Pradesh,Bengal, Khasi Hills and Western Ghats. Objectives of the present study were to determine antibacterial, antioxidant, anthelmintic and insecticidal efficacy of methanol extract of A. lakoocha fruit pericarp. Antibacterial activity was tested against by Agar well diffusion method. Antioxidant activity in terms of free radical scavenging ability was determined by DPPH free radical scavenging assay. Anthelmintic efficacy was determined using adult Indian earthworm. Insecticidal activity was tested against second and third instar larvae of Aedes aegypti. The extract has shown dose dependent antibacterial, antioxidant, anthelmintic and insecticidal activity. Among bacteria,S. aureus has shown more susceptibility than K. pneumoniae and P. aeruginosa. The extract exhibited marked antioxidant activity by scavenging DPPH free radical. The IC50 value for extract was found to be 49.42μg/ml. The extract exhibited marked anthelmintic activity by causing paralysis and death of worms and the effect was found to be dose dependent. The extract concentration 100mg/ml has shown marked anthelmintic effect than standard drug. In insecticidal study, the 2nd instar larvae were shown to be more susceptible than 3rd instar larvae. Phytochemical analysis revealed the presence of tannins and alkaloids. The presence of these phytoconstituents might be responsible for the biological activities of extract tested. The extract could be used to treat free radical damage, bacterial and helmintic infections and to control insect vectors. Further studies on isolation of constituents and their bio-efficacies in vitro and in vivo are under investigation.
Authors and Affiliations
Shailendra M. B, Rakesh M. C, Bharath. C, Vinod H. R. , Prashith T. R, Nandini. C, Rakshitha. N, Raghavendra. L
Keywords
Related Articles
- EP ID EP92481
- DOI -
- Views 165
- Downloads 0
ANTIDIABETIC EFFECT OF COMBINED AQUEOUS LEAF EXTRACT OF VERNONIA AMYGDALINA AND METFORMIN IN RATS
This study investigated the antidiabetic activity of the various combinations (ratios) of metformin (50 mg/kg) and aqueous extracts of the leaves of Vernonia amygdalina (100 mg/kg). The ratios of Extract to Metformin wer...
An Antioxidant potential of Hingot and Hadjod
The antioxidant activity of two plants - Hadjod i.e. Cissus quadrangularis (CQ) and Hingot i.e. Balanites aegyptiaca (BA) was determined by the thiocyanate method. The antioxidant activity of both the plants increa...
MAGNETIZED SOLUTIONS ALTERED THE ABSORBANCE OF TRAMADOL HCL: UV SPECTROPHOTOMETER STUDY
Magnetized water showed alterations in the electrolyte potential and vibration modes. This study aimed to investigate the effect of magnetic water and physiological solutions on the UV-spectra of tramadol HCl. Distilled...
Thrombolytic potential of Ocimum sanctum L., Curcuma longa L., Azadirachta indica L. and Anacardium occidentale L.
Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formed in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels...
Effects of ball-milling on PLGA polymer and its implication on lansoprazole-loaded nano particles
PLGA is a biodegradable polymer utilised widely in pharmaceutical research for the encapsulation of a wide range of drugs as nano particulate systems. This study investigates the impact of rotary ball milling on the phys...