Second Trimeter Recurrent Pregnancy Loss in Women with History of PCOS
Journal Title: Journal of Gynecological Research and Obstetrics - Year 2016, Vol 2, Issue 1
Abstract
Recurrent pregnancy loss (RPL) is one of the most frustrating and difficult areas in reproductive medicine because the etiology is often unknown. Hyperinsulinemia ascribed to PCOS and insulin resistance (IR) seem to be a contributing factor to RPL. The aim of this study was to assess the relationship between serum homocysteine level and insulin resistance in PCOS women with a history of send trimester recurrent pregnancy loss. The present study was carried out on 100 non-pregnant women in the reproductive period; their age ranged from 20 to 35 years. They were classified under two groups: Group 1: women having a history of second trimester recurrent pregnancy loss with PCOs (60 women). Group 2: women having a history of second trimester recurrent pregnancy loss and non-PCOs (40 women). We assessed plasma insulin and homocysteine (Hcy) levels in all cases. In addition, insulin resistance was determined using homeostasis model assessment (HOMA2-IR). The results: We found that homocysteine and insulin resistance are higher in PCOS women with recurrent pregnancy loss than non PCOS women. Conclusion: We conclude that that women with PCOS having a history of recurrent pregnancy loss had a higher serum level of homocysteine and a higher score of HOMA2-IR women without PCOS.
Authors and Affiliations
MN EL Gharib, TM El Sabae, MM Mabrouk
Keywords
Related Articles
- EP ID EP336979
- DOI 10.17352/jgro.000006
- Views 107
- Downloads 0
The Importance of Initial Evaluation by Trans Vaginal Sonography in Rudimentary Horn Pregnancy: A Case Report and Literature Review
Rudimentary horn pregnancy (RHP) as a rare incidence has been estimated at 1:76,000-1:150,000 pregnancies. It has been also reported that 80-90% of RHP lead to uterine rupture in second trimester. Early diagnosis with th...
Human zygote reconstruction by spindle, polar body or pronuclear transfer to treat repeated embryo fragmentation or embryo developmental arrest: the future is now
A common and very difficult issue to overcome as a clinical embryologist during an IVF cycle is the event of severe embryonic fragmentation or, more rarely, full developmental arrest. The current approach to bypass these...
Menstrual Stem cells
Stem cells isolated from menstrual fluid have mesenchymal stem cell like properties and have multi-lineage differentiation capacity. Menstrual fluid has ease of access in collection and repeated sampling is possible in a...
The hypoxia index covers roles of all decelerations and will reduce cerebral palsy
It was strange that fetal outcome was vigorous in 3 late decelerations, but ominous when it repeated. It was thought that FHR decelerations expresses hypoxia, because the heart rate was fully parallel to rabbit PaO2, if...
Co2 Laser Treatment for Vaginal Intraepithelial Neoplasia, Assesment of Recurrence
Objective: To assess the response and evolution of vaginal intraepithelial neoplasia (VAIN) after CO2 laser treatment. Material and Methods: A retrospective study was conducted from a database of 139 women who had VAIN a...