Secretor Status and Phenylthiocarbamide (PTC) Taste Perception are Risk Factors for Pulmonary Tuberculosis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 12
Abstract
Aim: To examine whether or not non-secretion of ABH substances and non-tasting of PTC are risk factors exhibiting positive interactions for tuberculosis. Methodology: A total of 210 individuals comprising 110 tuberculosis patients (test group) and 100 apparently healthy subjects (control group) participated in this study. Secretors and non-secretors were determined among the study participants by haemagglutination inhibition test and Tasters and non-tasters were determined using phenylthiocarbamide (PTC) taste strips (0.0143 mg/strip). Results: Of the 110 tuberculosis patients, 65 (59.1%) and 45 (40.9%) were secretors and non-secretors respectively while 49 (44.5%) were tasters and 61 (55.5%) were non-tasters. Of the 100 control subjects, 78% and 22% were secretors and non-secretors respectively while 67% and 33% were tasters and non-tasters respectively. Non-secretors of ABH substances were significantly more associated with test patients than controls (χ2 = 8.62, df = 1, p = 0.002). Non-tasters of PTC were significantly more associated with test patients than controls (χ2=10.68, df=1, p=0.001). When combined, secretors and tasters were significantly lower in the test group than in the control group (χ2=13.44, df=1, p<0.001) while non-secretors and non-tasters were significantly higher in the test group than in the control group (χ2=9.77, df=1, p=0.002). Individuals who were both non-secretors and non-tasters were significantly associated with tuberculosis compared to those who were not (OR 3.5; 95% C.I 1.59-7.51). Conclusion: This study shows that there is a remarkable increased incidence of tuberculosis in individuals who are both unable to secrete ABH substances and taste PTC.
Authors and Affiliations
C. Igbeneghu, B. M. Okanlawon, J. M. Olisekodiaka
Keywords
Related Articles
- EP ID EP341296
- DOI 10.9734/BJMMR/2016/27953
- Views 69
- Downloads 0
Bone Marrow Mast Cell Density Correlates with Circulating Biomarkers of Bone Disease in Multiple Myeloma
Aims: There is increased mast cell density (MCD) in multiple myeloma (MM) bone marrow (BM) that is correlated with advanced disease stage. Mast cells (MCs) produce various mediators promoting MM growth and bone metabolis...
Comparison of Antiretroviral Therapy (ART) Efficiency and Different HLA Class II Haplotypes
Aims: One of the ways to treat HIV/AIDS is Antiretroviral therapy (ART), which consists different schemes and includes numbers of drugs. However, in view of the HLA polymorphism it is necessary to determine the best asso...
Prevalence of Smokeless Tobacco Use and Number of Users in 121 Countries
Background: In 2010, a study estimated the number of smokeless tobacco (SLT) users in 70 countries at 302.4 million. These countries represented 70% of the global population. We aimed to update this information and widen...
Corneal Abrasion and Visual Evoked Potentials Monitoring: Causes and Prevention
Aims: The objective of this review is to explore the methods of eye protection from corneal abrasions during general anesthesia as they relate to procedures utilizing visual evoked potentials (VEP) monitoring. Because th...
Surgery as a Career Choice among Medical Undergraduates in a Developing Country
The distribution of medical manpower among various specialties should be of interest to government, health administrators and medical educators of any nation. The medical specialties chosen by medical undergraduates as t...