Sedative and anticonvulsant properties of <i>passiflora edulis</i> dried leaves decoction in mice
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2004, Vol 1, Issue 1
Abstract
[i]Passiflora edulis[/i] Sims is native from Tropical area of South America. It is used in traditional medicine in the treatment of some diseases related to the nervous system and others. The extract of [i]Passiflora edulis[/i] possesses sedative activity in mice. It significantly increased the total sleep time induced by diazepam (50 mg/kg i.p.). The total sleep time increased from 31 + 11 min in the control group to 77.6 + 15 and 78.3 + 16 min in the groups treated with extract at the doses of 132.5 and 1325 mg/kg respectively. This extract showed also anticonvulsant activity in mice. It protected mice against strychnine -induced seizures and antagonized N-methyl-D-aspartate- induced turning behavior in mice. The ED[sub]50[/sub] for the protection against seizures -induced by strychnine was 320 mg/kg intraperitoneally (i.p.). For N-methyl-D-aspartate -induced turning behavior, the ED[sub]50[/sub] was 300 mg/kg i.p. [i]Passiflora edulis[/i] extract had less effect against pentylene tetrazol- induced seizures. The potentiation of diazepam-induced sleep, the antagonism of chemical -induced seizures and turning behavior suggest that Passiflora edulis extract possess sedative and anticonvulsant properties in animals.
Authors and Affiliations
Elisabeth Bum, Esther Ngah, Benoite Ekoundi, Christian Dong, Rigobert Ayissi Mbomo, Silvere Rakotonirina, Alice Rakotonirina
Keywords
Related Articles
- EP ID EP128714
- DOI -
- Views 78
- Downloads 0
DETERMINATION OF PESTICIDE RESIDUES IN KHAT LEAVES BY SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
The purpose of this investigation is to develop a simple method for the assessment of pesticides in Khat leaves, Catha edulis FORSK. (Celastraceae) shrub, chewed by about 60 % of the Yemeni people, producing amphetamine-...
TRADITIONAL MEDICINE IN LATE PREGNANCY AND LABOUR: PERCEPTIONS OF KGABA REMEDIES AMONGST THE TSWANA IN SOUTH AFRICA
In South Africa most black women use antenatal care services and deliver in clinics, and a considerable number complement this use of formal health services with traditional medicine. This study reported here examined th...
HYPOGLYCAEMIC AND ANTIDIABETIC EFFECT OF ROOT EXTRACTS OF CEIBA PENTANDRA IN NORMAL AND DIABETIC RATS
The effect of the root bark extract of Ceiba pentandra (Linn) in normal and streptozotocin-induced diabetic rats was studied. Blood glucose levels were determined after oral administration of graded doses of C. pentandra...
Traditional medicine development for medical and dental primary health care delivery system in Africa
Traditional African Medicine (TAM) is our socio-economic and socio-cultural heritage, servicing over 80% of the populations in Africa. Although, it has come a long way from the times of our ancestors, not much significan...
IN VITRO AMOEBICIDAL ACTIVITY OF SOME MEDICINAL PLANTS OF THE BAMUN REGION (CAMEROON)
Fifty two medicinal plants belonging to different families selected on the basis of their traditional use against jaundice and various liver disorders were tested for their amoebicidal activities. They were extracted an...