Sedative and hypnotic effect of clonidine in mice
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 3
Abstract
Anxiety states and sleep disorders are common problems and sedative, hypnotic and anxiolytics are the most commonly prescribed drugs. Benzodiazepines are the commonly used sedative and hypnotic drugs .They are often associated with adverse effects like excessive drowsiness, tolerance and dependence. Hence there is always a need for newer drugs with less side effects. Clonidine is a 2 agonist which possess anxiolytic, sedative and hypnotic effects. In this study sedative and hypnotic effect of clonidine is compared with diazepam in mice. Sedative effect was measured using actophotometer and hypnotic effect was measured by prolongation of ketamine induced hypnotic time in mice. Clonidine showed significant sedative and hypnotic effects in mice.
Authors and Affiliations
Dr. S. Jeya Ponmari
Keywords
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