Abstract

Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor. Preformulation is the first step in the rational formulation of an active pharmaceutical ingredient (API). For any formulation interactions studies are very important. When there was no interaction between the choosen drug- excipient or excipient-excipient then the formulation will be a appropriate one. The selection of suitable study method to evaluate the interaction between the drug and the excipients is a prime most achievement in the pre-formulation study. The objective of the study was to study the compatibility of drug and polymers like sodium alginate, HPMC and ethylcellulose employed in the preparation of tablets for controlled drug delivery system by adopting Differential Scanning Calorimetric (DSC) study and Fourier transform Infra red spectrophotometric study (FTIR). Based on the DSC and FTIR results Cefixime was found to be compatible with excipients sodium alginate.

Authors and Affiliations