SELEKTIVNA IMUNOTERAPIJA POMOĆU HIMERA DOBIJENIH MOLEKULARNIM INŽENJERINGOM
Journal Title: Acta Facultatis Medicae Naissensis - Year 2011, Vol 28, Issue 1
Abstract
U mnogim fiziološkim procesima peptidi imaju ključnu ulogu kao neurotransmiteri, hormoni, antibiotici itd. Imaju istraživački značaj na poljima poput imunologije, farmakologije, neronauke i biologije ćelije. Postoje mnogi pristupi imunoterapijama: neki od njih koriste peptide kao važne komponente himeričnih molekula za imunosupresiju, drugi za vakcine bazirane na peptidnoj imunostimulaciji. Ove imunoterapijske strategije su u prednosti jer su bezbedne, jednostavne za primenu, lišene onkogenog potencijala i mogu biti formirane u konformaciono aktivne forme pomoću hemijskog ili genetskog inženjeringa. Ovi peptidi sadrže veoma važan funkcionalni deo, epitop, koga imuni sistem prepoznaje, naročito antitela, B i T ćelijski receptori. Epitopi igraju važnu ulogu kod vakcina baziranim na peptidnoj imunostimulaciji i mogu se koristiti u dijagnostičke svrhe. Peptidi dobijeni proteinskim ili genetskim inženjeringom vezani za antitela-nosače mogu poslužiti za predavanje epitopa ciljanim ćelijama.
Authors and Affiliations
Nikolina Mihaylova, Andrey Tchorbanov
Keywords
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