SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS): AN APPROACH TO ENHANCE AN ORAL
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 2
Abstract
Approximately 40%of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system because of their low bioavailability. The oral bioavailability of poorly water soluble drugs may be enhanced when co administered with meal rich in fat has led to increasing recent interest in the formulation of poorly water soluble drugs in lipids. One of the most new way for such a mentioned problem is the Self microemulsifying drug delivery system (SMEDDS). Self micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in water microemulsion upon mild agitation following dilution with aqueous phase. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form and the small size of the formed droplet provides a large interfacial surface area for drug absorption. This article gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules.
Authors and Affiliations
MOHITE P. B, HARISHCHANDREV S
Keywords
Related Articles
- EP ID EP435184
- DOI -
- Views 193
- Downloads 0
IN SILICO STUDIES ON Tithonia Diversifolia DERIVED PHYTOCHEMICALS AS POTENT INHIBITOR OF CYCLOOXYGENASE
Objectives: Prostaglandins released by the activity of the bifunctional enzyme, cyclooxygenase (COX) are involved in physiological functions such as protection of the stomach mucosa, aggregation of platelets and regulati...
MINERAL CONTENTS, ANTINUTRIENT CONTENTS AND FREE RADICAL SCAVENGING ABILITY OF PROCESSED UNDERUTILIZED BEANS IN NIGERIA
Objective: Bean seeds are important staple foods in Nigeria due to their nutritive values and relatively low cost. African Yam beans (AYB) (Sphenostylis stenocarpa) also known as 'Otili' is an underutilized beans that is...
A REVIEW ON CLINICAL TRIALS: WHY TO INTRODUCE ZERO PHASE
Objective: The main objective of this study is to know clinical trials in nutshell and phase 0 clinical trial are to establish at the very earliest opportunity-before large numbers of patients have been accrued and expos...
PRODUCTION OF L-ARGINASE UNDER SSF AND ITS OPTIMIZATION
Objective: The present study deals with the fermentative production of l-arginase under solid state fermentation technique .Various nutritional as well as physical parameters were altered in order to maximize the yield....
DESIGN, DEVELOPMENT FORMULATION AND INVITRO DISSOLUTION STUDIES OF SUSTAINED MATRIX COATED TABLETS OF METFORMIN HYDROCHLORIDE
The main objective of the present work was to develop sustained release matrix tablets of Metformin hydrochloride using different polymers viz. Hydroxypropyl methyl cellulose (HPMC) and natural gums like Guar gum and Eud...