Sen and Torque Teno Virus: Putative agents of Non-A-E Viral Hepatitis
Journal Title: Journal of Immunology and Vaccine Technology - Year 2015, Vol 1, Issue 2
Abstract
Introduction: The past few decades have witnessed formidable advances in the characterization of hepatotropic viruses of humans. A proportion of acute and chronic hepatitis cases still remain that cannot be ascribed to Hepatitis A-E viruses or to other viruses like certain Enteroviruses, Adenoviruses, Parvovirus B19 etc. The TTV and the SEN viruses are often present in the serum of individuals at high risk of infection with bloodborne viruses. Knowledge on TTV and SEN-V is growing fast, but many fundamental aspects remain to be elucidated. This study was undertaken to study the prevalence of TTV and SEN virus in patients with acute and chronic liver disease and to assess their role in liver disorders. Methodology: The study was conducted in Jawaharlal Nehru Medical College and hospital over a period of two years. 135 patients of liver disorder were included in the study. Screened was done for HAV, HCV, HEV IgM antibodies and HBV (anti HBsAg) by ELISA. Detection of TTV and SEN-V was done by nested PCR. Statistical analysis: Statistical analysis was performed with the IBM SPSS Statistics 19. Result: HBV was detected in 62(46%) cases. 34(25.2%) were positive for SEN virus, 20(15%) had TTV, 5(3.7%) had HEV, 3(2.2%) had HCV and 1(0.7%) had HAV infection. TTV was detected in 1(3.3%) healthy control while SEN-V was not detected in any of the healthy controls. Isotype SEN-H was detected in 58% of SEN-V patients and SEN-D in 38%. AVH was the most common presentation of TTV (60%) and SEN-V (64.7%). Clinically fever and icterus were consistent findings along with ascitis and abdominal discomfort. MELD score was greater than normal almost unvaryingly in all these patients. Conclusion: Our study points to a greater potential of SEN-V in causing hepatitis compared to TTV.
Authors and Affiliations
Fatima Khan
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