Senescence of osteogenic cells. Review.
Journal Title: Ortopedia Traumatologia Rehabilitacja - Year 2007, Vol 9, Issue 1
Abstract
In older individuals the regeneration of bone tissue is delayed due to the diminished activity of osteoblasts, while osteogenic potency of human bone marrow stromal cells, also capable of forming bone, does not change with age. The number of osteoprogenitor cells is not reduced in ageing subjects, but their proliferating rate and the activity of their derivatives--osteoblasts, is markedly diminished, since the self-renewing potential of these cells is hindered. The senescence of osteoblasts in ageing people is also accelerated. Changes within the bone marrow microenvironment reduce osteogenic potential of osteoprogenitor cells leading to impaired bone formation seen in senility, while the potency for ectopic osteogenesis does not change with age. This review summarizes documented mechanisms of changes in osteogenic activity of cells in elderly.
Authors and Affiliations
Krzysztof H Włodarski, Paweł K. Włodarski, Ryszard Galus
Keywords
Related Articles
- EP ID EP56677
- DOI -
- Views 90
- Downloads 0
Postural Balance in the Early Post-Operative Period in Patients with Intervertebral Disk Disease Following Surgery
Introduction: The authors assumed that advanced lumbar disk disease contributes to disorders of body equilibrium and asymmetry of foot pressure force on the ground. Surgery improves biomechanical relations in the lumbar...
Effectiveness of Physiotherapy in the Treatment of Excessive Lateral Pressure Syndrome after Anterior Cruciate Ligament Reconstruction - Preliminary Report
Background. The excessive lateral pressure syndrome is a common complication following anterior cruciate ligament (ACL) reconstruction is. It may lead to premature wear of the articular surfaces of the femur and patella....
Ocena efektów zastosowania tyzanidyny w leczeniu bólów kręgosłupa
Wstęp. Ból kręgosłupa to częsta przyczyna sprowadzająca pacjenta do lekarza. Ze względu na powszechność zjawiska oraz coraz młodszy wiek pacjentów z tego typu dolegliwościami, zespoły bólowe kręgosłupa zalicza się do sch...
Porównanie wyników radiologicznych operacyjnego leczenia skrzywień piersiowo-lędźwiowych w skoliozach idiopatycznych metodą spondylodezy tylnej i przedniej „kość na kość”
Wstęp. Celem operacyjnego leczenia skolioz jest maksymalna korekcja skrzywienia przy możliwie minimalnej liczbie usztywnionych segmentów kręgosłupa. Powszechnie akceptowane są dwie metody operacyjne: spondylodeza tylna i...
Orthopedic Procedures in Patients with Congenital Coagulation Disorders: Single Center Experience
Background. Spontaneous intraarticular bleeds in congenital coagulation disorders result in early and extensive damage to the joints and periarticular structures. Total arthroplasty is the only effective method of treati...