Sentinel Ganglion
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 16, Issue 2
Abstract
Sentinel lymph node technique is well known among physicians who treat breast cancer or melanoma but is roll in colorectal cancer is still under investigations. We made an analysis of this simple technique that could be applied is order to make a more precise stadification of colon cancer.Consecutive colon cancer patients, candidates for surgical treatment were selected. The final sample was made of 43 patients. In the course of surgery once the specimen is removed, the ex-vivo blue methylene technique is performed. The blue methylene is injected into the tumour, using a total volume of 2 mL. The specimen is not opened. Thereupon the tumour is massaged for five minutes. Afterwards the sentinel nodes, now dyed, are sought in the mesocolon and then removed. The extracted lymph nodes are subjected to the OSNA (One Step Nucleic acid Amplification) technique, which has a high sensitivity in the detection of lymph node metastasis. This amplification method is being able to identify copies of RNAm of the cytokeratin CK19, which is plentiful in tumour cells but absent in normal lymph nodes. For the rest of the lymph nodes in the specimen, conventional histopathological work up was performed.
Authors and Affiliations
Carlos Álvarez Laso, Jonás García, Enedina Azcano González, Diana Rodríguez Rodríguez
Keywords
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