Sepsis-associated acute kidney injury – is it possible to move the needle against this syndrome?
Journal Title: Jornal de Pediatria - Year 2017, Vol 93, Issue 1
Abstract
On the one hand, sepsis is the leading cause of non-trauma related death in pediatric patients across the world, in both developed and developing nations.1 On the other hand, epidemiologic data demonstrate the independent contribution of acute kidney injury (AKI) to morbidity and mortality in both adults and children.2,3 The mortality, morbidity, and financial cost of AKI is significant and has led to dedicated global initiatives to eliminate preventable AKI and mitigate the effects of existent AKI.4 Together, unfortunately, sepsis and AKI synergize into the “worst of both worlds” – inciting a litany of negative host responses and ultimately leading to poor patient outcome. In this issue of Jornal de Pediatria, Riyuzo et al.5 report data on the predictive factors of death in patients with sepsis associated AKI. In their retrospective evaluation of 77 children with sepsis and AKI, the rate of severe AKI (pRIFLE stage I–F and/or stage 2–3 were both over 75%) and the overall mortality rate was substantial (33.7%).
Authors and Affiliations
Rajit Basu
Keywords
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- EP ID EP510367
- DOI 10.1016/j.jped.2016.09.001
- Views 56
- Downloads 0
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