Sequential, Multimodal Treatment of a Refractory Adult-Onset Still’s Disease Complicated by Reactive Hemophagocytic Lymphohistiocytosis
Journal Title: Clinical Medical Reviews and Case Reports - Year 2016, Vol 3, Issue 7
Abstract
We report the case of a patient with severe adult-onset Still's disease not responding to treatment with high-dose corticosteroids and intravenous immunoglobulins. Partial remission was obtained under therapy associating anakinra and leflunomide but subsequently she developed acute hepatitis and disseminated intravascular coagulation consistent with a reactive hemophagocytic lymphohistiocytosis. The patient was successfully treated with a combination of tocilizumab, cyclosporine and corticosteroids leading to a prolonged remission.
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- EP ID EP268518
- DOI 10.23937/2378-3656/1410117
- Views 129
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