SERINE PROTEASE INHIBITORS AS POTENTIAL THERAPEUTIC AGENTS: A PERSPECTIVE
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 11
Abstract
Serine proteases play a major role in various biological processes like cell signalling, digestion, immune responses, blood clotting and extracellular matrix remodelling. The dysregulation of serine proteases during diseased conditions ranging from cancer and inflammatory disorders to degenerative diseases and colitis represents their importance in various physiological conditions. One of the effective ways to regulate their effect is by inhibiting the proteolysis using protease inhibitors. Understanding the role and the underlying mechanism played by serine proteases and their inhibitors in various pathological conditions offer novel strategies for therapeutic intervention. Scientific reports highlight the effectiveness and potency of small cyclic peptides as protease inhibitors. Small cyclic peptides are advantageous over linear or high molecular weight protein inhibitors because of their stability and efficacy. The bioavailability of cyclic peptides is more due to their cell penetrating behaviour.
Authors and Affiliations
Dr. Sneharani A. H.
Keywords
Related Articles
- EP ID EP630412
- DOI -
- Views 117
- Downloads 0
ASSOCIATION BETWEEN POLY CYSTIC OVARIES SYNDROME AND SERUM LEVEL OF CHROMIUM, ZINC AND MAGNESIUM
Background Polycystic ovary syndrome (PCOS), as the most prevalent endocrine disorder in reproductive-aged women, is associated with reproductive and metabolic abnormalities. Despite the large literature on the role of d...
DIGIT RATIO AS AN INDEX OF NUMERICAL AND VERBAL INTELLIGENCE: A STUDY OF ACADEMIC STAFF IN THE HARDCORE SCIENCE AND HUMANITIES IN RIVERS STATE, NIGERIA
Digit ratio is regarded as a physiological marker for the prenatal concentration of the sex hormones; testosterone and oestrogen, which organise the architecture of the body and the brain and the distribution of hormone...
LAPAROSCOPIC RESECTION OF A SIGMOID COLO - VESICAL FISTULA
Colo vesical fistula can be a result of a variety of conditions. Patients commonly present with lower urinary tract symptoms (LUTS) and recurrent urinary tract infections (UTI).The management is surgical resection. Urina...
CONTRIBUTION TO THE BIOTECHNOLOGICAL POTENTIAL STUDY OF ISOLATED LACTIC LEVAINS OF FERMENTED CASSAVA FOR THE PRODUCTION OF ADJOUKROU, AHIZI AND EBRIÉ ATTIÉKÉ
The current work aims to study the typology of the lactic starter isolated from the fermented cassava for the production of Adjoukrou, Ahizi and Ebrié attiéké. The objective is to highlight the contribution of autochthon...
PTERIONAL MENINGIOMA: A CASE REPORT AND CLINICAL DISCUSSION
Meningioma is characterized as an abnormal meningeal growth from the arachnoid-mater that is usually benign. It is among the most common primary intracranial neoplasms and can be found in 1%-2.3% of autopsies. Despite th...