Sero-Activity of Chikungunya Virus at the Kenyan Coast after the 2004 Epidemic
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Chikungunya virus (CHIKV) is an alphavirus of Semliki Forest virus antigenic complex. Seroprevalence of CHIKVwas measured after the reported 2004CHIKV epidemic in Coastal Kenya and factors associated with seropositivity determined.The total anti-CHIKV antibodies were measured by in-house ELISA’s and neutralizing antibodiesdetermined by focus reduction neutralization test (FRNT) in a cross sectional serosurvey, comparisons of means done using Student’s t test, prevalence rates determined using descriptive statistics, tests of associations performed using Chi-square, and Fisher’s exact test.Of 452 samples, 134 (29.6%) were seropositive for CHIKV antibodies by in-house ELISA; 105 (23.2%) had CHIKV neutralizing antibodiesby FRNT. Age, the month of July, and herding wereassociatedwith CHIKV seropositivity;OR=0.53 (P=0.051, 95% CI: 0.28-1.02), OR=0.14 (P=0.012, 95% C.I 0.02 – 0.8) and OR=6.34 (P= 0.014, 95% CI:1.55-30.61) respectively. Myalgia is likely present in CHIKV infection odds 3.72 (P=0.0363, 95% CI: 1.10-13.53). CHIKVis endemic at the Kenyan coastand poses a high risk on socio-economic development. There is need for frequent serosurveys to enhance targeted preventive public health interventions and new control paradigms.
Authors and Affiliations
Veronicah K . Anjichi1, Gabriel Magoma, Shingo Inoue4, A. Ole Kwallah3,, Charles K. Syengo, Caroline Ndege, Kouichi Morita4, Katherine Munyuga, Matilu Mwau2,3,
Keywords
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- EP ID EP387008
- DOI 10.9790/3008-1106042331
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