Sero-Prevalence Of Dengue Infection By Rapid Immunochromatographic Device For The Detection Of NS1, IgM, IgG Antibodies To Dengue Viruses From A Tertiary Care Hospital
Journal Title: Malla Reddy Medical College For Women Journal Of Medical Sciences - Year 2019, Vol 2, Issue 1
Abstract
Background: Dengue infection is an acute febrile endemic viral disease mostly prevalent in the tropical countries. The serological diagnosis of primary dengue infection is made by detection of NS1 antigen which is important for early (Day 1-7 of fever) and accurate diagnosis of dengue. Material and methods This study aimed to evaluate the prevalence of dengue infections by using Rapid Immuno-Chromatographic card Test detecting NS1 Antigen, Anti-IgM and Anti-IgG Dengue virus antibodies among clinically suspected Dengue virus infections from patients attending a tertiary care hospital.This study was conducted in the form of retrospective study where total of 566 serum samples received in serology section with working diagnosis of Dengue fever were subjected to Dengue virus screening for NS1, Anti-IgM and Anti-IgG Antibodies done by using Rapid Immuno-chromatographic Card Tests. Observations and discussion: Of 566 clinically diagnosed dengue fever cases, 117 (20.6%) were positive for Dengue NS1 antigen alone , IgM alone 4(0.7%), IgG alone 15(2.6%). Conclusion: Rapid Immuno chromatographic card tests are simple, feasible, cost-effective, less time consuming, with less labor involved, where sensitivity and specificity are good, but this card tests are only a screening test and so it cannot be used as a stand-alone test for diagnostic confirmation. , but it could be supplemented with another diagnostic assays like ELISA for Dengue NS1, IgM and IgG, Indirect Immuno fluorescence and Polymerase Chain Reaction for appropriate diagnosis of DENV infection
Authors and Affiliations
Swathi C. M
Keywords
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