Seroprevalence of Cytomegalo Virus Infection among HIV Patients Accessing Healthcare in Federal Medical Centre Keffi, Nigeria
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2016, Vol 17, Issue 3
Abstract
Background: Cytomegalovirus (CMV) a herpes virus known for latency after primary infection is a major cause of morbidity and mortality in HIV/AIDS patients. It is reported to enhance HIV replication and acceleration of HIV infection to AIDS. Aim: There is a dearth of published information on the prevalence of CMV infection among HIV/AIDS patients in this area. This cross sectional study was designed to determine the prevalence and risk factors for the viral infection among HIV/AIDS patients in Keffi. Methods: Blood samples from 208 HIV patients were screened for CMV using specific CMV IgG Enzyme Linked Immunosorbent Assay (Cortez diagnostic Inc, USA) according to the manufacturer’s instructions. Results: The overall prevalence of CMV IgG antibody was 77.0%. The prevalence of viral infection based on sex was found to be 82.6% among the males and 75.3% in females (P >.05). Seroprevalence was found to be highest among those aged 10–20 years (90.9%) and least among those aged 41-50 years (68.8%) (P >.05). There was a statistically significant association between the viral infection and CD4 cells count (P .05). HIV patients with CD4 of < 100 cells/l reported the highest prevalence (100%). There was a decrease in prevalence with an increase in CD4 cell counts. Conclusion: This study reported 77.0% CMV infection among HIV patients with low CD4 counts as a risk factor. Marital status, occupation, level of education, residence and antiretroviral therapy status had no statistically significant association with CMV infection (P >.05). The threat of CMV reactivation and consequent sequelae among those seropositive to IgG must not be overlooked in the study population. HIV patients should therefore be monitored closely for clinical signs of CMV syndrome.
Authors and Affiliations
G. R. Pennap, H. O. Ahmed
Keywords
Related Articles
- EP ID EP329138
- DOI 10.9734/IJTDH/2016/27030
- Views 74
- Downloads 0
Knowledge, Attitudes and Practice of Contraception among Refugees in a Refugee Settlement in Yaoundé, Cameroon
Introduction: Despite the benefits of family planning, contraceptive use has been found to be limited among refugees. Aim: This study aimed at assessing knowledge, attitude and practice of contraception among refugees in...
Parasitological Assessment and Public Health Implications of Water Used for Domestic Purposes in Ebonyi Local Government Area of Ebonyi State, Nigeria
Aims: Water-borne diseases have been a major cause of morbidity in most developing countries including Nigeria mainly due to poor quality of water used for domestic and industrial purposes. This study was on the parasito...
Omphalitis in a Nigerian Neonate; Lessons to learn
We present a four day old male neonate who presented at the special care baby unit of the University Teaching Hospital, Ado–Ekiti with features of peri-umbilical cellulitis. The factors that predisposed to the developmen...
Comparison of School Health Services among Private and Government Owned Schools of Belgaum
Introduction: Children are the creators and the shapers of tomorrow and school marks an important early milestone in the child’s life long journey of intellectual and psychological development. Objective: To assess the...
Pattern of Bednet Ownership and Usage of Insecticide Treated Bednet (ITN) among Pregnant Women in Nigeria (Review of 2003 and 2008 National Demographic and Health Survey [NDHS]
Introduction: Malaria in pregnancy imposes great burden on the country in terms of maternal morbidity, anaemia and low birth weights for children. World Health Organization (WHO) recommends insecticide-treated nets (ITN)...