Seroprevalence of HBsAg, Anti-HCV and Anti-HIV in Hemophilia ‘A’ and ‘B’ Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 5
Abstract
The aim of the study was to find out seroprevalence of HBsAg, anti-HCV and anti-HIV in hemophilia “A” AND “B” patients. To find out the association of hepatitis B, hepatitis C and HIV infection with various factors like age, sex, family history, number of transfusions of blood products and factor concentrates. It was a hospital based cross sectional descriptive study. Hemophilia affected children were selected and evaluated in detail with regards to the age of onset of symptoms, mode of presentation, family history of bleeding/ hemophilia, severity of bleeding episodes and their relation to trauma , number of bleeding episodes with respect to time, most common site of bleeding, most common joint involved, therapies taken for bleeding episodes including blood products and / or factor concentrates, number of times therapy being taken, response to therapy, age of using blood product / factor for the first time, prophylactic or episodic (on demand) therapy. This study revealed that infection rates were higher with higher number of blood products transfusion. Hemophiliacs who received only factor concentrates were less prone for infection with above studied viral infection as compared to the ones who received blood products. Hence, we recommend the use of factor concentrates over blood products in hemophilia patients. Also, routine screening, for transfusion related infections like HCV is advisable for better outcome. Keywords: Hemophilia, Blood transfusion, Hepatitis, HIV, Clotting Factors.
Authors and Affiliations
Mallikarjun R Kobal, Rakesh Navale, Prashant Gadgi, Rohit Dixit
Keywords
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