Seroprevalence of transfusion-transmissible infectious agents (HIV, HBV, HCV, plasmodium species and treponema pallidum infections) among blood donors at a Tertiary Care Teaching Hospital in Chennai: Changing trends over a period of five years
Journal Title: Indian Journal of Microbiology Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction Transfusiontransmissible infections TTI are principal threat to the recipient of a blood transfusion Consequently Drugs and cosmetics act asserts that mandatory screening tests must be performed to rule out TTI human immunodeficiency virus HIV hepatitis B virus HBV hepatitis C virus HCV Plasmodium species and Treponema pallidum The principal intention of this study was to resolve the seroprevalence and inclining trends of TTI amongst blood donors at a tertiary care teaching hospital in ChennaiMaterials amp Methods A detailed retrospective study and analysis of successive blood donorsboth voluntary and replacement records covering over the period from January 2010 and December 2014 was carried out Statistical analysis was performed to establish the trends interconnected with TTIResults 2006 12 donor blood samples from 165809 successive blood donors were tested to be serologically reactive for at least one infectious agent amongst which 140008 samples tested contained more than one TTI agents Correspondingly on the whole seroprevalence of TTI agents HIV HBV HCV Plasmodium sp and Treponema pallidumnbspinfections was 004 114 0022 00006 and 00006 A statistical significant correlation was identified between HBV and HIV viral infections Furthermore appreciably declining tendency in seropositivity of HIV Plasmodium sp and Treponemanbspinfections and continuing increasing drift of perilous HBV and HCV seroreactivity was identified throughout the study phaseConclusion A considerably significant fraction pool of blood donations spread HIV HBV and HCV infections Compulsory screening of donors blood with stringent selection of voluntary blood donors along with by prescribed standard techniques are particularly recommended to guarantee the protection of recipient undergoing blood transfusionKeywords Drugs and cosmetics act 1940 Mandatory screening test Seroprevalence TransfusionTransmissible Infectious TTI Agentsnbsp
Authors and Affiliations
D. Umesh, Aparna V. , S. Padma
Keywords
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- EP ID EP473822
- DOI 10.18231/2394-5478.2018.0006
- Views 42
- Downloads 0
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