SERUM ADROPIN AND ADIPOSE FATTY-ACID BINDING PROTEIN AT 6TH WEEK OF PREGNANCY ARE SIGNIFICANT PREDICTORS FOR DEVELOPMENT OF INSULIN RESISTANCE AT THE 24TH WEEK.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 2
Abstract
Objectives: To estimate serum Adropin (ADR) and Adipose fatty-acid-binding proteins (AFABP) levels at 6th wk and its relations with insulin resistance (IR) judged by homeostasis model assessment of IR (HOMA-IR) score and their predictive value for later development of gestational diabetes mellitus (GDM). Patients & Methods: 335 pregnant women gave blood samples for estimation of fasting blood glucose (FBG), and fasting serum insulin, ADR and AFABP. All women underwent the 75-Oral glucose tolerance test (OGTT) and HOMA-IR scoring at 6th and 24th week GA. Results: At 6th wk GA, 77 women had IR score >2 and 24th wk 39 women developed GDM and 106 had IR >2. Mean 6th wk serum ADR levels were significantly lower, while serum AFABP levels were significantly higher in GDM than non-GDM women. Statistical analyses defined 6th wk GA high serum AFABP and insulin, BMI and 2-hr PPBG, and low serum ADR, as significant predictors for development of IR at the 24th wk GA. Conclusion: Pregnancy induces maternal IR that was related to maternal BMI and may progress to GDM that was reported by a frequency of 11.9%. Development of GDM and IR were closely related to high serum AFABP and low serum ADR levels
Authors and Affiliations
Amr Sharafeldeen, Raafat R. . Mohammed
Keywords
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- EP ID EP278041
- DOI 10.21474/IJAR01/6496
- Views 92
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