Serum Aluminium Levels in Stage 4, 5 & 5D Chronic Kidney Disease
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 4
Abstract
Objectives: Use of non aluminum containing phosphate binders and improvement in feed water quality for hemodialysis (HD) have resulted in low prevalence of aluminum toxicity. The study was undertaken to detect the prevalence of high serum Al levels in chronic kidney disease (CKD) patients & controls. Settings & Design: Cross sectional study carried out at a tertiary care teaching hospital. Methods: We analyzed the serum aluminum levels in 32 CKD patients & 32 controls. It was one time sample check. The levels were correlated with anemia, Serum PTH levels, neurologic features if any. Iron status was noted in all. Results: All 32 CKD patients were anemic with Hb levels between 7 to 10 gm%. None were on any medication containing aluminum. Al level in our institute tap water & R.O. Water was < 5μg/l. Six volunteers showed Serum Al level range between 5 to15 μg/l while it was undetectable in remaining 26 volunteers. All 32 CKD patients had Serum Al > 5μg/l: 23 with 5 to 40 μg/l, 8 with 40 to 200 μg/l & one > 200 μg/l. Of 23 pts [in range 5 to 40 μg/l], 19 were on Maintenance HD while 4 were pre –HD. All 8 patients [in range 40 to 200 μg/l] & the one with S.Al > 200 μg/l were on HD. The difference in serum aluminium levels in two groups [Control Vs CKD] was significant (p< 0.001). The co-relation between serum Al level and Calcium (p- 0.21), as well as iPTH (p- 0.42) were not significant. None had any neurologic features. Conclusions: Serum aluminum was detectable in only 23% of controls but 100% in CKD patients. Though detectable, the levels were not significant in controls. However, 28% of CKD had S.Al >40 μg/l. Though it is a small study group, it highlights significantly higher levels, the source of which needs to be looked into.
Authors and Affiliations
Sandip P. Bhurke, Kalpana S. Mehta, Rudramani Swami, Amol Bhagat, Atim Pajai
Keywords
Related Articles
- EP ID EP546849
- DOI 10.21276/ijmrp.2017.3.4.038
- Views 88
- Downloads 0
A Study of Psychiatric Comorbidity in Alcohol Dependent Patients in North-West Rajasthan
Background: Comorbidity indicated the presence of a individual clinical existence that has survive or may occur during the clinical course of a patient having the index disease. Though alcohol is one of the usually drugs...
Clinico-Pathological Study of Brain Tumors with Special References to Atypical Cases: A Retrospective Analysis of 130 Cases in a Tertiary Care Hospital in India
Context: Brain tumors are heterogeneous group of neoplasms, which can occur at any age. Despite of some published articles regarding pathological pattern of brain tumors from different parts of the world and in India, co...
Multiple Autoimmune Diseases: Celiac Disease, Autoimmune Hypothyrodism, Diabetes Mellitus, Addison’s disease in Lady 14 Years Old
Multiple autoimmune diseases are rare to see in a single patient. The concept of three autoimmune diseases or more in a single patient defined as multiple autoimmune syndrome (MAS). We describe a case of a young woman wi...
Comparative Evaluation of Prognosis of Patients with Hip Fracture among Different Age Groups: An Institution Based Study
Background: Hip fracture is one of the common fractures reported among both the young and elderly population in the recent time. Approximately 60 to 80 percent of the patients with hip fractures have been reported to be...
Evaluation of Anemia in Hospitalised Infants at a Tertiary Care Hospital
Anemia is a significant public health problem that occurs worldwide in both developed and developing countries. Aim of the present study was to evaluate the pattern of anemia among hospitalized infants. The Prevalence of...