Serum Amyloid A and Lipoprotein Associated Phospholipase A2 Levels in Patients with Malign Melanoma: Correlations with Clinical Assessment and Stage
Journal Title: Türk Dermatoloji Dergisi - Year 2018, Vol 12, Issue 3
Abstract
Objective: The lack of validated, sensitive, and specific biomarkers for early diagnosis and follow-up of patients with malign melanoma (MM) is a major problem today. In this study, we aimed to investigate the correlations of two inflammatory biomarkers-serum amyloid A (SAA) and lipoprotein associated phospholipase A2 (Lp-PLA2)-in clinical follow-up and staging of MM. Methods: Lactate dehydrogenase (LDH) and C-reactive protein (CRP) (Routine), SAA and S100B (ELISA), and Lp-PLA2 (PLAC® Test) activity levels were examined in histologically and clinically confirmed MM patients (n=131) and in healthy controls (n=27). Results: Sedimentation rate and LDH, CRP, S100B, SAA, Lp-PLA2 activities were found to be significantly higher in MM patients compared to control group (p<0.05). SAA showed the strongest correlation with disease stage (Spearman’s correlation coefficient=0.622, p=0.000). Receiver operating characteristic analysis revealed that SAA exhibited the largest area under the curve=0.984, p=0.000, highest sensitivity (95%) and specificity (93%). Pearson’s test indicated a weak positive correlation between SAA levels and Lp-PLA2 activity (r=0.311, p=0.000). Conclusion: This is the first study to evaluate the activity of inflammatory biomarker Lp-PLA2 in melanoma patients. Both SAA and Lp-PLA2 were in highest levels in stage 4 patients, and they are thought to be candidate biomarkers to be used in detecting tumor progression. According to our results, SAA is the biomarker which correlates best with disease stage in MM.
Authors and Affiliations
Yavuz Kayaş, Ferhan Sağın, Yasemin Akçay, Gizem Kocabaş Yenipazar, Elif Azarsız, Eser Sözmen, Fezal Özdemir, Işıl Karaarslan
Keywords
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- EP ID EP381338
- DOI 10.4274/tdd.3643
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