Serum Amyloid A and Lipoprotein Associated Phospholipase A2 Levels in Patients with Malign Melanoma: Correlations with Clinical Assessment and Stage
Journal Title: Türk Dermatoloji Dergisi - Year 2018, Vol 12, Issue 3
Abstract
Objective: The lack of validated, sensitive, and specific biomarkers for early diagnosis and follow-up of patients with malign melanoma (MM) is a major problem today. In this study, we aimed to investigate the correlations of two inflammatory biomarkers-serum amyloid A (SAA) and lipoprotein associated phospholipase A2 (Lp-PLA2)-in clinical follow-up and staging of MM. Methods: Lactate dehydrogenase (LDH) and C-reactive protein (CRP) (Routine), SAA and S100B (ELISA), and Lp-PLA2 (PLAC® Test) activity levels were examined in histologically and clinically confirmed MM patients (n=131) and in healthy controls (n=27). Results: Sedimentation rate and LDH, CRP, S100B, SAA, Lp-PLA2 activities were found to be significantly higher in MM patients compared to control group (p<0.05). SAA showed the strongest correlation with disease stage (Spearman’s correlation coefficient=0.622, p=0.000). Receiver operating characteristic analysis revealed that SAA exhibited the largest area under the curve=0.984, p=0.000, highest sensitivity (95%) and specificity (93%). Pearson’s test indicated a weak positive correlation between SAA levels and Lp-PLA2 activity (r=0.311, p=0.000). Conclusion: This is the first study to evaluate the activity of inflammatory biomarker Lp-PLA2 in melanoma patients. Both SAA and Lp-PLA2 were in highest levels in stage 4 patients, and they are thought to be candidate biomarkers to be used in detecting tumor progression. According to our results, SAA is the biomarker which correlates best with disease stage in MM.
Authors and Affiliations
Yavuz Kayaş, Ferhan Sağın, Yasemin Akçay, Gizem Kocabaş Yenipazar, Elif Azarsız, Eser Sözmen, Fezal Özdemir, Işıl Karaarslan
Keywords
Related Articles
- EP ID EP381338
- DOI 10.4274/tdd.3643
- Views 93
- Downloads 0
Autoimmune Progesterone Dermatitis: Two Case Reports
Autoimmune progesterone dermatitis is a rare hypersensitivity reaction that develops against endogenous progesterone. This condition is characterized by cutaneous and mucocutaneous findings that begins cyclically in the...
Isotretinoin is a Safety Therapy on Kidney: A Retrospective Study
Objective: Isotretinoin is widely used in severe acne treatment. The drug leads to several adverse effects; skin and mucous membranes are frequently affected. It may also cause serious and fatal adverse effects like kidn...
Pachydermodactyly
.
Cutaneous Cytology and Tzanck Smear Test
.
A Case Report: Subcutaneous Myiasis Caused by Dermatobia Hominis After a Trip to Brazil
Myiasis is an invasive diseases caused by larvae of various Dipterian flies. Subcutaneus myiasis cases are commonly observed by Dermatobia hominis larvea. A 26-year-old female patient with a history of travel abroad. Br...