Serum Angiopoietin-2 and Soluble Thrombomodulin in Patients with Systemic Lupus Erythematosus and their Relation to Disease Activity and Renal Affection
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Background: Several lines of evidence demonstrate excessive endothelial activation in systemic lupus erythematosus (SLE). Angiopoietin-2 (Ang-2) and soluble thrombomodulin (sTM) are two biomarkers of endothelial cell activation that may be clinically useful in SLE. Objective: to examine the clinical utility of two proposed biomarkers of endothelial activation; angiopoietin-2 and soluble thrombomodulin in SLE correlating their serum concentration with disease activity and renal affection. Subjects and methods: Ang-2 and sTM were measured in sera obtained from 60 patients with SLE (6 male patients and 54 female) and 30 healthy controls by ELISA methodology. Disease activity was calculated according to the SLE Disease Activity Index (SLEDAI). Patients were classified according to disease activity and renal involvement. Results: Both Ang-2 and sTM concentrations were increased in patients with SLE in comparison to controls (P<0.001). Both Ang-2 and sTM were significantly higher in the active group and active nephritis subgroup in comparison to inactive group and active patients without nephritis, respectively (P<0.001). Both markers were positively correlated with SLEDAI and protein/ creatinine ratio. Serum www.jmscr.igmpublication.org Impact Factor 1.1147 ISSN (e)-2347-176x Salwa Ibrahim Bakr et al JMSCR Volume 2 Issue 6 June 2014 Page 1392 JMSCR Volume||2||Issue||6||Page 1391-1405 ||June 2014 2014 Ang-2 was superior to serum sTM as predictor of SLE activity and discriminator of lupus nephritis Conclusion: Elevated concentrations of circulating sTM and Ang-2 can serve as biomarker of disease activity and renal affection in SLE. Serum Ang-2 was superior to serum sTM as predictor of SLE activity and nephritis. Further studies should be conducted to put serum Ang-2 as a candidate drug target where functional blockade could seem to protect against endothelial damage in such disease.
Authors and Affiliations
Salwa Ibrahim Bakr
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