Serum Apolipoprotein A-Iv Level in HCV Related Liver Diseases
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 12
Abstract
Background: Hepatitis C virus (HCV) is a globally prevalent pathogen and chronic infection eventually causes cirrhosis leading to hepatocellular carcinoma (HCC) and ultimately death. Accurate assessment of liver fibrosis has become increasingly important as it allows for individualized management. Liver plays a key role in the metabolism of plasma apolipoproteins. Apolipoprotein A-IV (apoA-IV) is a component of intestinally derived, triglyceride-rich lipoproteins. Objective: The present work was designed to study the level of apo A-IV in HCV related liver diseases. Methods: Sixty treatment-naive patients with HCV related liver disease were enrolled in the study. They were classified as follow: twenty patients with chronic HCV infection (stage of fibrosis ≤ F3), twenty patients with HCV related liver cirrhosis, twenty patients with HCV related HCC and ten normal subjects as control. Serum level of apoA-IV was measured using enzyme linked immunosorbant assay (ELISA). Liver biopsies from patients with chronic HCV were examined to assess histological activity grade and fibrosis stage according to METAVIR scoring system and triphasic CT for HCC patients was performed. Results: Apo A-IV level was significantly lower in liver cirrhosis than chronic hepatitis patients with a cutoff point of ˂36.4 (p<0.001). The receiver operating characteristic (ROC) curve showed an area under the curve (AUC) of 0.990 (P < 0.001), a sensitivity of 100% and a specificity of 90% for diagnosis of cirrhosis. Also, it was significantly lower in liver cirrhosis than HCC patients with a cutoff point ≤25.1 (p<0.001). The ROC showed AUC of 0.876, a sensitivity of 80.0 % and a specificity of 93.33% for diagnosis of HCC. Conclusion: Serum apo A-IV showed bi-modal elevation in HCV related liver diseases and could be used as a noninvasive marker for liver cirrhosis in patients with chronic HCV infection and could be a promising marker for early detection of HCC in HCV hepatic cirrhosis.
Authors and Affiliations
Ibrahim E. H.
Keywords
Related Articles
- EP ID EP213094
- DOI -
- Views 69
- Downloads 0
Evaluation of Method for Glycated Hemoglobin and Its Correlation with Microalbuminuria as Early Markers of Nephropathy in Type II Diabetes Mellitus
Diabetic nephropathy is the leading cause of end stage renal disease and mortality. The aim of the study was (i) to correlate between two methods of HbA1c estimation; the column chromatography and the immunoturbidimetric...
Fine Needle Aspiration Cytology in Salivary Gland Swellings- A Cross Sectional Study in a Tertiary Care Centre
Background: Fine need aspiration cytology is the gold standard investigation in the work up of salivary gland tumors. This is one of the fast and cost effective investigations available. With the widespread availability...
Blood Loss after Total Knee Arthroplast
Total knee arthroplasty is associated with considerable blood loss[1,2]. Various measures which reduce effective blood loss include use of tourniquet[3], minimally invasive surgery[4].use of cautery. Sealing of femoral c...
A Retrospective Study of Drugs Suspected for SJS/TEN Reactions in a Tertiary Care Center of North India
Steven Johnson syndrome and Toxic epidermal necrolysis are types of severe adverse cutaneous reactions. Though they are rare, they are potentially fatal reactions endangering a patient's life. This retrospective study wa...
A Case of Hypothyroidism with Anti-dsDNA Negative Lupus Nephritis Presenting as Pericardial Effusion: A Diagnostic Dilemma
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that may involve many different organs and display a variable clinical course. From a pathogenetic point of view, the production of several autoant...