Serum Beta HCG and Fasting Lipid Profile in Early Second Trimester as Predictors of Gestational Hypertension
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 5
Abstract
Hypertensive disorders of pregnancy are one of the commonest medical problems encountered during pregnancy. It is the major cause of maternal and perinatal morbidity, complicating 5-10 % of pregnancies worldwide. A variety of biochemical and biophysical markers have been proposed for the purpose of predicting the development of gestational hypertension later in pregnancy. Early identification of at risk women may help in taking timely preventive and curative management to prevent or delay complications associated with gestational hypertension. The study aims at testing the hypothesis that women with high serum beta HCG and lipid profile in early second trimester have risk of developing gestational hypertension. 130 patients were included in the study using selection criteria. This prospective clinical study was being conducted in department of OBG, JMMC &RI in a time period of December 2013 to May 2015. The study group consisted of all pregnant women who were coming to the OBG department for antenatal visit except those who fall under exclusion criteria. Informed consent will be obtained as per proforma. Those with known last menstrual period or first trimester ultrasonography screening and gestational age between 14-20 weeks were selected irrespective of parity. Patients were screened for beta HCG and fasting lipid profile. The patients were followed up regularly in the antenatal OPD till delivery. All the detailed data were collected and data was analysed statistically. Total cholesterol, triglycerides, VLDL, and LDL values for those women who developed gestational hypertension were significantly higher than those who remain normotensive with p value of <0.05 which is statistically significant. HDL and beta HCG values for gestational hypertensive group were not higher than those in normotensive group with p value >0.05 which is statistically insignificant. Maternal lipid profile in second trimester is very good noninvasive test which can be used for prediction of gestational hypertension before its clinical onset. However, there is no correlation between maternal serum beta HCG and gestational hypertension. Keywords: Gestational hypertension, beta HCG, total cholesterol, triglyceride, LDL, VLDL, HDL.
Authors and Affiliations
Dr. Archana. S, Dr. Sareena Gilvaz, Dr Bindu M, Dr Arya R Nair, Dr Amit Kamat
Keywords
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