Serum chemerin level and its relation to carotid intima media thickness in type 2 diabetic patients
Journal Title: JOURNAL OF ADVANCES IN BIOLOGY - Year 2015, Vol 7, Issue 3
Abstract
Background: The central pathological mechanism in macrovascular complications of T2DM is the atherosclerotic process. Measuring carotid intima media thickness [CIMT] was found to be suitable to detect the early stages of atherosclerosis. altered chemerin secretion may be of pathological relevance to various disorders including diabetes mellitus and atherosclerosis. The aim: to evaluate the relation of serum chemerin levels with early stages of atherosclerosis measured by CIMT in patients with T2DM without established coronary artery diseases (CAD) compared to healthy control subjects. Patients and methods: The study included 86 subjects divided into two groups: Group I: included 46 T2DM patients without CAD. Group II included 40 healthy control subjects matched for age and sex. All subjects were subjected to the following: full history taking, complete clinical examination, body mass index [BMI] and laboratory assessment included fasting glucose, insulin level, glycated hemoglobin [HbAIc], lipid profile. Serum chemerin levels and homeostasis model assessments (HOMA2-IR). Doppler ultrasound for carotid artery to determine CIMT. Results: BMI, Fasting plasma glucose, Triglyceride, HbAIc, HOMA2- IR, CIMT and serum chemerin levels were statistically significantly higher in diabetic group than the controls. Serum chemerin level had statistically significant positive correlation with BMI, LDL-c, FBG, HOMA2.IR, HbAIc and CIMT. The CIMT had statistically significant positive correlation with BMI, HBAIc and serum chemerin level. Conclusions: Serum chemerin level positive correlation with BMI and HOMA2-IR may indicated the relation between chemerin and DM. CIMT and serum chemerin positive correlation to each other and to HbAIc may indicated their relation to atherosclerosis.
Authors and Affiliations
Dr Eman Badr, Mohamed A. Korani, Ashraf A. Zeiton
Keywords
Related Articles
- EP ID EP654496
- DOI 10.24297/jab.v7i3.4588
- Views 151
- Downloads 0
Production And CharacTeristics of A Bioflocculant Produced By Pseudomonas SP. STRAIN 38A
Screening of microorganisms producing flocculating substances was achieved. A strain secreting a large amount of bioflocculant was isolated from wastewater samples collected from the inlet from Borg El-Arab industrial wa...
Attenuating effects of pentoxifylline on memory, oxidative stress and monoamine levels in the hippocampus of seizure induced mice.
Lithium pilocarpine (Li-Pc) - induced seizures in rodents serve as convenient animal models to study the mechanisms of epileptogenesis particularly with reference to the development of status epilepticus (SE), memory ret...
Structural DNA Nanotechnology: From Design to Applications
Structural DNA Nanotechnology applies modified DNA strands to come up with various shapes and order of arrangements of DNA molecules as desired. This DNA specimen is produced by exchange of DNA backbones in a reciprocal...
The effect of jujube oil on some biological activities of Culex pipiens mosquito
Synthetic insecticides are quick, effective and most popular methods of pest control. But because of their unfavorable effects on environment and non-target organisms, there is a growing need to find new, safe effective...
Reorganization of the cytoskeleton
The effect of a modulated electromagnetic field on the cytoskeleton is possible through the action of voltage-sensitive phosphatase (VSP). Field-controlled phosphorous hydrolysis could have important roles in cytoskeleto...