Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2
Journal Title: Global Journal of Obesity, Diabetes and Metabolic Syndrome - Year 2017, Vol 4, Issue 3
Abstract
Aim: The present study was intended to establish the role of bone in grade III obese women with and without type 2 diabetes mellitus (T2DM). Material & Methods: Serum osteocalcin (OC), Beta Cross-Laps (Beta-CTx), parathormone (PTH) separar and y 25-hydroxyvitamin D (25OHD) concentrations were measured in 48 morbid obesity women (11 with T2DM and 37 control group). Insulin resistance and insulin secretion was assessed by measuring the HOMA-IR and the HOMAβ index and its association with OC and Beta-CTx. Results: Serum OC was significant lower in the diabetic group compared with non-diabetic patients 15.4 ± 3.6 ng/ml vs 22.1 ± 3.5 ng/ml, p<0.001 without significant differences in Beta-CTx (0.24 ± 0.1 vs 0.31 ± 0.2 ng/ml, ns). Both bone biomarkers, OC and Beta-CTx, showed a positive correlation (r=0.76; p<0.01) in the whole group subjects and in the control group (r=0.80, p<0.00), but no in the T2DM group (r=0.50, p ns). In the whole group of patients, OC correlated significantly with HOMA-IR (r=0.36; p<0.01) and HOMA-ß (r=0.36, p<0.01). Beta-CTx also correlated with HOMA-IR (r= 0.40, p<0.01) and HOMA-ß (r= 0.41, p<0.001. OC also significantly correlated with HOMA-IR (r=0.41, p<0.01) in non-diabetic patients and almost reached statistical significance with HOMA-ß (r=0.32, p=0.053), but was not significantly correlated with HOMA-ß (r= -0.53, ns) and with HOMA-IR index (r=0.52, ns) in the T2DM group. When we performed the multivariate logistic regression the serum level of OC was the only covariate found significantly with DM2 with a coeficient -6.65 , (95% CI, -12.75049 -.5674469 ); p = 0.03). Both groups showed secondary hyperparathyroidism (T2DM, 78.4 ± 19.4 pg/ml vs non-diabetic group, 75.4 ± 35.6 pg/ml; ns). The majority of the patients showed 25OHD deficiency 62.5%, followed by 25OHD insufficiency 27.1% and normal 25OHD levels in only 10.4%. The 25OHD deficiency was present in both study groups (T2DM patients, 18.3 ± 7.4 pg/ml and nondiabetic group, 19.7 ± 9.6 pg/ml; ns). Conclusion: OC and Beta-CTx could play a role in glucose metabolism and insulin resistance. Serum OC concentrations are significantly reduced in T2DM morbidily obese women compared with non-diabetic group, and add new evidence on the possible role of bone as an endocrine organ with metabolic implications specially the levels of OC.
Authors and Affiliations
Arrieta F, Iglesias P, Piñera M, Quiñones J, Balsa J, Vazquez C
Keywords
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- EP ID EP347022
- DOI 10.17352/2455-8583.000029
- Views 83
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