Serum Cystatin C and Creatinine level among Chronic Kidney Disease Patients Undergoing Hemodialysis
Journal Title: Scholars International Journal of Biochemistry - Year 2018, Vol 1, Issue 4
Abstract
Chronic kidney disease (CKD) is one among the slowly progressive diseases of kidney function characterized generally by low glomerular filtration rate (GFR). The replacement therapy of renal failure by hemodialysis involves the removal of excessive toxic fluids and toxic metabolic end products from the body. The present study aimed to assess serum Cystatin c and creatinine (pre and post) in CKD patients undergoing hemodialysis. The study included 50 patients with CKD who undergo dialysis. Serum creatinine and urea measured in pre and post-dialysis by colorimetric method, cystatin c was measured by using metric immunoassay. The data were analyzed using SPSS version 21. The results revealed that the mean of serum creatinine level in post-hemodialysis patients (3.05±1.12) were lower significant compared to pre-hemodialysis (8.76±2.26) p-value 0.000, also serum urea level in post-hemodialysis patients (90.30±17.11) were lower significantly compared to pre-hemodialysis (176.58±26.72) p-value 0.000, serum Cystatin c level in post-hemodialysis patients (6.91±0.93) were higher significantly compared to pre-hemodialysis (6.34±1.51) p-value 0.007. There was a significant difference in the levels of serum urea and creatinine observed Pre and Post hemodialysis with respect to different age groups P-value 0.002 and 0.021while no significant difference in serum Cystatin c level observed Pre and Post hemodialysis with respect to different age groups P-value 0.119. The findings of this study, hemodialysis leads to decreased serum urea and creatinine level in patients with CKD under hemodialysis and decreased the increased cystatin c level.
Authors and Affiliations
Hana Basher Hassan Wagealla, Salih Abdelgadir Elmahdi, Ismail Mohamed Ismail, AbdElkarim A. Abdrabo
Keywords
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