Serum enzyme levels as biomarkers in malaria
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 1
Abstract
Malaria is one of the most serious diseases especially of the tropical world. Pathophysiological process involves both centrilobular liver damage and red blood cells destruction. As a result, enzymes present in these cells are released into circulation. The present study was undertaken to determine the diagnostic value of serum Lactate Dehydrogenase (LDH), Alkaline Phosphatase (ALP), Aspartate Transaminase (AST), Alanine transaminase (ALT) - Liver function biomarkers and LDH, Acid Phosphatase (ACP) - RBC function biomarkers, in patients with acute uncomplicated malarial infection. The study group consisted of 130 subjects, of age groups 20-50 years and of both sexes. Of these, 50 had vivax malaria, 30 had falciparum malaria and 50 were healthy individuals as controls. They were confirmed to be positive for Plasmodium Vivax/ Falciparum parasite by microscopical examination of Giemsa stained blood slides. Results showed that the serum levels of all enzymes are elevated in both vivax & falciparum malaria patients when compared to controls. The increase in ACP, ALP, ALT, AST is statistically significant (p<0.05) while increase in LDH is statistically highly significant (p<0.001) in vivax malarial patients. Also, the increase in ALP, ALT, AST is statistically significant (p<0.05) while increase in ACP, LDH is statistically highly significant (p<0.001). Hence, serum enzymes can be utilized extensively for both definitive and supportive diagnosis of Malaria in clinical scenario. Keywords: Malaria, vivax, falciparum, serum enzymes
Authors and Affiliations
Dr T. Anil Kumar, Dr B. Lakshmi Keerthana
Keywords
Related Articles
- EP ID EP370897
- DOI -
- Views 78
- Downloads 0
Comparison of Cardiorespiratory Effects during Intrathecal Bupivacaine
Intrathecal injections of opioids like buprenorphine have been reported to cause anti-nociception in animals and pain relief in human beings including the potentiation of local anaesthetic action in the spinal cord. The...
Symbolic Case of a DiffueChorangiomatosis without Foetal Impact with a Review of the Literature
Most of the macroscopically visible abnormalities of the placenta are of no functional significance, the major exception to this general banality being the uncommon large haemangioma or diffuse chorangiomatosis which can...
Study on dyslipidemia and oxidative stress in Elderly- A clinical approach to predict cardiovascular disease risk
Abstract: Aging is characterized by systemic deterioration of biomolecules and increased incidence of oxidative stress. In addition, occurrence of dyslipidemia in elderly significantly contributes the development of card...
Prevalence of Awareness and Knowledge of Glaucoma in Urban Puducherry
Glaucoma represents a major public health challenge in ageing population. Glaucoma is the second leading cause of avoidable blindness globally and third cause in India. The aim of the study is to assess the awareness and...
Milk of Calcium in Pelvicalyceal System of Kidneys Mimicking Contrast in Pelvicalyceal System – A Case Report
Abstract: Milk of calcium of the kidneys and nephrolithiasis are two different entities. Milk of calcium in the pelvicalyceal system can mimic calculus and contrast in the pelvicalyceal system if bilateral. Their differe...