Serum Enzymes in Organophosphorous Poisoning
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 6
Abstract
Organophosphorus compounds have been widely used for a few decades in agriculture for crop protection and pest control. In India Organophosphorus poisoning is the most common. Acetylcholinesterase is an enzyme that breaks down the neurotransmitter acetylcholine results in a lowered level of acetylcholine, and ultimately the termination of nerve impulses. Organophosphorous compounds covalently block the active site of serine residue of acetylcholinesterase this irreversible inactivation leads to an excess accumulation of acetylcholines in the peripheral and central nervous system causing cholinergic manifestations. We have estimated the serum enzymes such as acetylcholinesterase, lactate dehydrogenase, creatine kinase, amylase and lipase in organophosphorus poisoning patients and healthy controls. We found significantly decreased acetylcholinesterase (p<0.001) and significantly increased lactate dehydrogenase, creatine kinase, amylase and lipase in patients with organophosphorus poisoning as compared to controls (p<0.001). Serum acetylcholinesterase level was estimated only at the time of admission. Daily estimation of acetylcholinesterase and amylase levels may provide more informative in prediction the prognosis or severity of poisoning and to monitor the effectiveness of therapy.
Authors and Affiliations
Dr Karan Ningappa Pujari
Keywords
Related Articles
- EP ID EP213668
- DOI -
- Views 60
- Downloads 0
Corelation of Sehgal Index and Rbc Indices For Screening of Beta Thalassemia Trait
Background: Hemoglobinopathies are a group of disorders of hemoglobin synthesis characterized by the absence or reduction of one or more of the globin chains of hemoglobin. Materials and Methods: This is an observational...
Assessment of Some Health-Related Practices and Knowledge among a Group of Egyptian Patients with Peptic Ulcer Disease
Background: Peptic ulcer disease had a tremendous effect on morbidity and mortality until the last decades of the 20th century, when epidemiological trends started to point to an impressive fall in its incidence due to t...
Mullerian Duct Anomalies: Diagnostic Impact of Magnetic Resonance Imaging
Aim: The aim of the present work is to evaluate the value of magnetic resonance imaging (MRI) in assessment of Mullerian duct anomalies. Patients and Methods: The study was performed on 20 female patients having clinical...
Recanalisation of Multiple Vitellointestinal Duct after Small Bowel Obstruction in Adult- A Rare Case Presentation
Patent vitello-intestinal duct is an unusual congenital disease, occurs in about 2% of the population1 , which may lead to small intestinal obstruction and other complications, like abdominal pain, intestinal haemorrhage...
Dermatosis in New Born a Clinical Study
There are few studies on new born dermatosis in our country. The aim of present study is to know the incidence of cutaneous changes in our area. Influence of Sex, birth weight and duration of gestation on early neonatal...