SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE AND LIPIDS IN YOUNG ADULTS WITH UNCOMPLICATED ESSENTIAL HYPERTENSION
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 3
Abstract
Introduction: Gamma-glutamyl transpeptidase initially used as an indicator of alcohol ingestion is now viewed as a sensitive marker of sub clinical inflammation. Recent clinical studies have shown its association with blood pressure and lipid profile. As GGT degrades glutathione, an antioxidant GGT can be considered as a pro inflammatory marker playing a role in atherogenesis and hypertension. Materials and methods: 65 subjects with Essential hypertension and 50 age and sex matched healthy controls both male and female between 18-50 years of age were recruited from General Medicine department of Narayana Medical college and Hospital, Nellore, A.P. Serum GGT was measured by calorimetric kinetic assay. Fasting Serum Triglycerides, Total Cholesterol and HDL cholesterol by standard enzymatic procedures and LDL cholesterol by Friedwald equation. Results: GGT is significantly elevated in hypertensive subjects (Mean±SD 64.2±18.62IU/L) compared to controls (Mean±SD 26.20±8.91IU/L) (P value <0.001). GGT is significantly correlated with systolic BP (r= 0.26 p<0.01) and diastolic BP(r= 0.28 p<0.01). Conclusion: Our findings suggest that elevated GGT in young adults may contribute to their susceptibility to hypertension and provide an additional evidence of novel role of GGT in cardiovascular risk evaluation.
Authors and Affiliations
Rajarajeswari D| Dept of Biochemistry, Narayana Medical College and Hospital, Chinthareddy Palem, Nellore, Andhra Pradesh, India.524003, Corresponding author email: bio.rajeswari@gmail.com, Ramalingam| Dept of Biochemistry, Narayana Medical College and Hospital, Chinthareddy Palem, Nellore, Andhra Pradesh, India.524003, Sharmila T| Dept of Biochemistry, Narayana Medical College and Hospital, Chinthareddy Palem, Nellore, Andhra Pradesh, India.524003, Prasad Naidu M| Dept of Biochemistry, Narayana Medical College and Hospital, Chinthareddy Palem, Nellore, Andhra Pradesh, India.524003, Naidu JN| Dept of Biochemistry, Narayana Medical College and Hospital, Chinthareddy Palem, Nellore, Andhra Pradesh, India.524003
Keywords
Related Articles
- EP ID EP11467
- DOI 10.5958/2319-5886.2015.00111.3
- Views 285
- Downloads 33
Polymorphisms of HLA Class I and II Alleles in Iraqi Patients with Hepatic Hydatid Infection
Background: Hepatic hydatid disease (HHD) is a parasitic zoonosis caused by larval stage of Echinococcus tape worm. In addition to environmental factors, genetic constitution of hosts seems to play a crucial role in acq...
ETIOLOGY AND TREATMENT OUTCOME OF PEDESTRIANS WITH TRAUMATIC BRAIN INJURIES FROM ROAD TRAFFIC CRASHES
Context: That unconscious man on the road being taken into the ambulance was knocked down by a vehicle. The energy he absorbed from the impact was proportional to the weight of the vehicle with its occupants, and to t...
EFFECTS OF HAND WASH AGENTS: PREVENT THE LABORATORY ASSOCIATED INFECTIONS
Background: The aim of this study was to find out the prevalence of bacteria and their antimicrobial susceptibility pattern in hands of the laboratory workers. Laboratory associated infections are an occupational hazar...
LATE ONSET HEMORRHAGIC DISEASE OF NEWBORN DUE TO CMV HEPATITIS PRESENTING AS SCALP HEMATOMA
Vitamin K deficiency bleeding (VKDB) according to recent studies is the preferred term for hemorrhagic disease of the newborn (HDN). This is due to deficiency of clotting factors as a result of vitamin K deficiency. VK...
GENDER DIFFERENCES IN AUTONOMIC FUNCTIONAL STATUS IN RESPONSE TO STRESS
Introduction: Men and women are similar in their cognitive appraisal of a stress. But their behavior is different when exposed to stress. As stress responses and cognitive abilities are closely associated with autonomi...