SERUM LEAD, CADMIUM AND MERCURY LEVELS IN NIGERIAN BATTERY REPAIR WORKERS: CORRELATIONS WITH PLASMA LIPIDS.
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 2
Abstract
Background: Lipid and lipoprotein abnormalities play a major role in the pathogenesis and progression of atherosclerosis as well as other cardiovascular diseases. These have been associated with an increased blood lead, mercury and cadmium levels. This study was therefore designed to determine the association between chronic occupational exposure to lead, cadmium and mercury on plasma lipids. Subjects and Methods: Sixty battery repair workers who have been on the job for at least 5 years and sixty apparently healthy, age and sex matched controls were consecutively enrolled for the study. Serum was extracted from 6mls of venous blood collected from subjects and controls after an overnight fast. Demographic and anthropometric parameters were obtained using semi-structured questionnaires. Serum levels of lead (Pb), cadmium (Cd) and mercury (Hg) were measured by atomic absorption spectrophotometer. Total Cholesterol (T-Chol), Triglycerides (Tg) and High Density Lipoprotein-Cholesterol (HDL-Chol) were measured using commercially prepared reagents manufactured by Randox Laboratories Limited, United Kingdom. Low Density Lipoprotein – Cholesterol (LDL-Chol) was calculated using Friedewald equation Results: The serum levels of Cd (0.36 ±0.11 μg/dl vs 0.25±0.05μg/dl), Pb (0.09±0.14μg/dl vs 0.03±0.01μg/dl) and Hg (0.06±0.05μg/dl vs 0.02±0.01μg/dl) were significantly higher among battery repair workers than control subjects, p<0.01 respectively. Furthermore, there was statistically significant increase in LDL-Chol (2.60±1.17mmol/L vs 1.73± 0.45 mmol/L), Total Cholesterol (4.35± 0.81 mmol/L vs 3.70 ±.38 mmol/L) and Triglyceride (0.63± 0.43 mmol/L vs 0.37± 0.22 mmol/L) with corresponding decrease in HDL-Chol (1.35±0.81 vs 1.67±0.33 mmol/L) among battery repair workers When compared with controls. Significant negative association was observed between HDL-Chol and Cd (r = -0.328, p<0.05) among battery repair workers. Conclusion: Increased serum levels of Cd, Pb and Hg among battery repair workers may potentially increase the risk of having dyslipidaemia and its associated complications.
Authors and Affiliations
Atiba A. S.
Keywords
Related Articles
- EP ID EP635372
- DOI -
- Views 158
- Downloads 0
ASSESSMENT OF COGNITO-MOTOR ACTIVITIES OF RATS EXPOSED TO MILD CRUDE OIL TOXICITY
This study examined the possible neurotoxic effects of Nigerian Bonny Light Crude Oil (NBLCO) by assessing antioxidant levels and cognito-motor functions in rats. Thirty healthy male and female albino rats of 12 weeks ol...
BIOCHEMICAL AND HISTOLOGICAL CHANGES IN KIDNEY AND HEART OF MALE RATS FOLLOWING ORAL ADMINISTRATION OF AQUEOUS AND METHANOLIC EXTRACT OF CANNABIS SATIVA LEAVES
The biochemical and histological changes in kidney and heart of male rats was evaluated following oral administration of aqueous and methanolic extract of Cannabis sativa (Marijuana) leaves. Twenty seven (27) male albino...
EFFECT OF COSTUS AFER ON FERTILITY PARAMETERS IN CYCLOPHOSPHAMIDE-INDUCED REPRODUCTIVE TOXICITY IN MALE ALBINO RATS.
CP is an anticancer and immunosuppressive agent commonly used in men of reproductive age. This study was aimed at determining the effect of the ethanolic extract of Costus afer on the reproductive system of rats treated...
EFFECT OF AGING ON SERUM CALCIUM, MAGNESIUM AND PHOSPHOROUS IN HEALTHY ADULT.
The effect of aging were studied in serum calcium ,magnesium and phosphorous as bone mineral in Sudanese healthy adult in four group (male and female from18-50 years as control group,male and female 55-72 years as case g...
COST-BENEFIT ANALYSIS OF PRENATAL DIAGNOSIS BY MOLECULAR KARYOTYPING VERSUS CONVENTIONAL KARYOTYPING FOR DETECTION OF ANEUPLOIDIES IN RAMATHIBODI HOSPITAL
Objective: To compare the benefit to cost ratio of prenatal diagnosis (PND) for aneuploidy between KaryoLite BACs-on BeadsTM (KL-BoBsTM) and conventional karyotyping techniques in health care purchaser's perspective. Stu...