Serum levels of SOD, MDA and glutathione peroxidase in different subtypes of cataract patients
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 3
Abstract
Background: Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants. Since the reactive oxygen species (ROS) generated from multiple sources is capable of producing deleterious effects. Body has its own defence mechanism against the oxidative damage by ROS. These defence strategies act in the form of Antioxidants. Methods: The present study was carried out in the Department of Biochemistry, Govt. Medical College, Amritsar in collaboration with Department of Ophthalmology, Ram Lal Eye Hospital, Amritsar attached to Govt. Medical College, Amritsar. 50 patients suffering from cataract attending the OPD and wards of Ramlal Eye Hospital diagnosed on the basis of history, clinical signs/symptoms and slit lamp examination were selected for the study. 50 age matched normal healthy individuals from the same population were selected to serve as controls. The comparison was done by students ‘t’ test on the number of variables for each parameter. Result: Our results confirm that oxidative stress is responsible for the development of all three subtypes of cataract. The use of antioxidants may be helpful to prevent or delay cataractogenesis. Conclusion: We found that there is a significant disequilibrium status of antioxidant system in serum in various types of agerelated cataract patients compared with the control group. The activities of SOD, GPx in cataract group were lower than those in the control group. The oxidative stress products MDA were significantly increased in serum of cataract patients.
Authors and Affiliations
Jaskiran Kaur, Anju Sharma, Sahiba Kukreja, Neha . , Amandeep Kaur, Mandeep Kaur
Keywords
Related Articles
- EP ID EP242688
- DOI -
- Views 91
- Downloads 0
Assessment of glycated hemoglobin and uric acid level in polycystic ovarian syndrome in a Tertiary Care Institute of Marathwada region
Introduction: The Polycystic Ovary Syndrome (PCOS) is one of the most common reproductive endocrine disorders, affecting 5–10% of women in the reproductive age. Insulin resistance is the hallmark of this disorder. PCOS h...
Evaluation of thyroid hormones in chronic kidney disease patients at tertiary care hospital- A comparative study
Introduction: The study is design to see the association between levels of thyroid hormones (Serum fT3, fT4 and TSH) and renal markers (serum urea, creatinine, and eGFR) in patients of chronic kidney disease (CKD). Hypot...
Effect of Hypothyroidism on lipid profile
Objective: To study the effects of subclinical and overt hypothyroidism on serum levels of low density lipoprotein(LDL), total cholesterol(TC), high density lipoprotein (HDL) and triglycerides(TG). And also to compare th...
Elimination of bilirubin interference by photolysis in the analysis of creatinine, glucose and alkaline phosphatase
Introduction: Clinical biochemistry laboratory uses many techniques for measuring the concentration of specific biochemical substances. All these techniques are subject to interference from variety of sources. The aim of...
Utilization of laboratory services and perspective of lab practices among clinicians: A cross sectional study
Introduction In recent years the care of patients has become increasingly dependent on the results of lab investigations Lab investigations have always been and will continue to be an integral part of clinical practice C...